Results 111 to 120 of about 16,307,918 (298)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16

Beilstein Journal of Organic Chemistry, 2013
A straightforward synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16 has been achieved following a sequential glycosylation strategy.
Manas Jana, Anup Kumar Misra
doaj   +1 more source

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific [PDF]

, 1998
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS, Christopher A. O'Callaghan, Philip J.R. Goulder, O'Callaghan, CA, Allen, RL, Anthony Kelleher, Andy K. Sewell, Jamie D.K. Wilson, Kelleher, A, Goulder, PJ, Andrew J. McMichael, Graham S. Ogg, Rachel L. Allen, Rowland-Jones, SL, Callan, MF, Wilson, JD, Sarah L. Rowland-Jones, Margaret F.C. Callan, Sewell, AK, McMichael, AJ   +19 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

GMMA-based vaccine candidates against invasive nontyphoidal salmonellosis elicit bactericidal antibodies against a panel of epidemiologically relevant Salmonellae

Frontiers in Immunology
Systemic disease caused by nontyphoidal Salmonella (NTS) represents a major cause of death and morbidity, especially in young children in sub-Saharan Africa.
Daniele De Simone, Marika Pinto, Maria Grazia Aruta, Marta Benincasa, Martina Carducci, Roberta Di Benedetto, Francesco Citiulo, Miren Iturriza, Elli Mylona, Stephen Baker, Mariagrazia Pizza, Carlo Giannelli, Francesca Mancini, Rocío Canals, Omar Rossi   +14 more
doaj   +1 more source

Variations in O-antigen biosynthesis and O-acetylation associated with altered phage sensitivity in Escherichia coli 4s

, 2020
© 2015, American Society for Microbiology. The O polysaccharide of the lipopolysaccharide (O antigen) of Gram-negative bacteria often serves as a receptor for bacteriophages that can make the phage dependent on a given O-antigen type, thus supporting the
Ovchinnikova O., Zdorovenko E., Larin A., Golomidova A., Letarov A., Knirel Y., Liu B., Prokhorov N., Shashkov A., Kostryukova E.   +9 more
core  

Concentration of protein and O-antigen in OMV samples.

, 2018
Concentration of protein and O-antigen in OMV samples.
Hemanta Koley (361307), Ritam Sinha (461919), Debaki R. Howlader (5748902), Priyadarshini Mukherjee (5748911), Ushasi Bhaumik (5748908), Shanta Dutta (185742), Suhrid Maiti (5748905)   +6 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Actinobacillus actinomycetemcomitans serotype d-specific antigen contains the O antigen of lipopolysaccharide

, 2003
Actinobacillus actinomycetemcomitans is a gram-negative, facultatively anaerobic bacterium which is associated especially with aggressive forms of periodontitis. Contradictory results on the localization of the A.
Asikainen, Sirkka,, Paju, S, Alfthan, G, Pussinen, PJ, Lakio, L, Tiirola, T   +5 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source