Polyvalent phage GSP004 recognizes O-antigen polysaccharide receptors in <i>Salmonella</i> and <i>Escherichia coli</i> through tail fiber protein ORF208. [PDF]
Gao D +6 more
europepmc +1 more source
Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang +7 more
wiley +1 more source
Disruptions in outer membrane-peptidoglycan interactions enhance bile salt resistance in O-antigen-producing <i>E. coli</i>. [PDF]
Qin J +4 more
europepmc +1 more source
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang +5 more
wiley +1 more source
Molecular epidemiology of Burkholderia pseudomallei in Hainan Province of China based on O-antigen. [PDF]
Huang J +9 more
europepmc +1 more source
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli +8 more
wiley +1 more source
High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach. [PDF]
Pearse O +10 more
europepmc +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Lactate metabolism is exploited by <i>Francisella tularensis</i> via its O-antigen capsule to limit macrophage-mediated activation and cell death. [PDF]
Jessop F +7 more
europepmc +1 more source

