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The Ongoing Journey of a Shigella Bioconjugate Vaccine
Vaccines, 2022 Shigellosis is a serious disease with a major impact, especially in low-income countries where mortality and morbidity are high. In addition, shigellosis among travelers and military personnel is a cause of significant morbidity and contributes to the ...
Patricia Martin, Cristina Alaimo
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Serotype O:8 isolates in the Yersinia pseudotuberculosis complex have different O-antigen gene clusters and produce various forms of rough LPS [PDF]
, 2016 InYersinia pseudotuberculosiscomplex, the O-antigen of LPS is used for the serological characterization of strains, and 21 serotypes have been identified to date.
MOLINARO, ANTONIO +13 more
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BMC Genomics, 2017 Background Shigella flexneri is the primary cause of bacillary dysentery in the developing countries. S. flexneri serotype 1c is a novel serotype, which is found to be endemic in many developing countries, but little is known about its genomic ...
Pawan Parajuli +2 more
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Enterobacterial Common Antigen: Synthesis and Function of an Enigmatic Molecule
mBio, 2020 The outer membrane (OM) of Gram-negative bacteria poses a barrier to antibiotic entry due to its high impermeability. Thus, there is an urgent need to study the function and biogenesis of the OM.
Ashutosh K. Rai, Angela M. Mitchell
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Mechanism of O-antigen distribution in lipopolysaccharide [PDF]
Journal of Bacteriology, 1990 O-antigen units are nonuniformly distributed among lipid A-core molecules in lipopolysaccharide (LPS) from gram-negative bacteria, as revealed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate; the actual distribution patterns are complex, multimodal, and strain specific.
R C, Goldman, F, Hunt
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Comparison of Shigella GMMA and glycoconjugate four-component formulations in animals
Frontiers in Molecular Biosciences, 2023 Shigellosis is leading bacterial cause of diarrhea with high prevalence in children younger than 5 years in low- and middle-income countries, and increasing number of reports of Shigella cases associated to anti-microbial resistance.
Roberta Di Benedetto +7 more
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Identification of the lipopolysaccharide O‐antigen biosynthesis priming enzyme and the O‐antigen ligase in Myxococcus xanthus: critical role of LPS O‐antigen in motility and development [PDF]
Molecular Microbiology, 2019 SummaryMyxococcus xanthus is a model bacterium to study social behavior. At the cellular level, the different social behaviors of M. xanthus involve extensive cell–cell contacts. Here, we used bioinformatics, genetics, heterologous expression and biochemical experiments to identify and characterize the key enzymes in M.
María Pérez‐Burgos +4 more
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Some Oral Pathogenic Bacteria, Isolation and Diagnosis
Journal of Pure and Applied Microbiology, 2018 The microbial community in oral cavity associated with oral infection and disease, variety of microbes have been recorded in oral cavity with different genetic properties, the present study aims to study some oral cavity isolates using classical ...
Mona Al-Terehi +3 more
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Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity
Vaccines, 2021 Self-assembling protein nanoparticles (SAPN) serve as a repetitive antigen delivery platform with high-density epitope display; however, antigen characteristics such as size and epitope presentation can influence the immunogenicity of the assembled ...
Cosette G. Schneider +12 more
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MicrobiologyOpen, 2019 The Wzx flippase is a critical component of the O‐antigen biosynthesis pathway, being responsible for the translocation of oligosaccharide O units across the inner membrane in Gram‐negative bacteria.
Michael A. Liu +2 more
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