Preference of Bacterial Rhamnosyltransferases for 6-Deoxysugars Reveals a Strategy To Deplete O-Antigens. [PDF]
J Am Chem Soc, 2023 Harnagel AP +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
RB49-like Bacteriophages Recognize O Antigens as One of the Alternative Primary Receptors. [PDF]
Int J Mol Sci, 2022 Efimov AD +5 more
europepmc +1 more source
Structural determination of the O‐antigenic polysaccharide from Escherichia coli O141 [PDF]
, 1998 Magnus Färnbäck +2 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Unique or not unique? Comparative genetic analysis of bacterial O-antigens from the Oxalobacteraceae family. [PDF]
Vavilovskii Zhurnal Genet Selektsii, 2022 Afonnikova SD, Komissarov AS, Kuchur PD.
europepmc +1 more source
Erratum to: Structural Relationships Between Genetically Closely Related O-Antigens of Escherichia coli and Shigella spp. [PDF]
, 2018 Yu. A. Knirel +8 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Rapid generation of Shigella flexneri GMMA displaying natural or new and cross-reactive O-Antigens. [PDF]
NPJ Vaccines, 2022 Gasperini G +9 more
europepmc +1 more source