Results 11 to 20 of about 2,031 (173)

Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta [PDF]

Biomedicine & Pharmacotherapy, 2020
Special attention is required when pharmacological treatment is indicated for a pregnant woman. P-glycoprotein (MDR1) is a well-known transporter localized in the maternal blood-facing apical membrane of placental syncytiotrophoblast and is considered to
Bakos, Éva, Hirschmugl, B., Pilarova, V., Sucha, S., Székely, V., Tupova, L., Özvegy-Laczka, Csilla   +6 more
core   +4 more sources

Identification of centrally active drugs and herbal constituents as substrates of OATP2B1 and OATP1A2 applying the method of competitive counterflow [PDF]

, 2021
For a large number of compounds in clinical use we know that membrane transporter proteins modulate their pharmacokinetic properties. The family of organic anion transporting polypeptides (OATP) facilitates the cellular entry of such compounds.
Schäfer, Anima
core   +3 more sources

Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer. [PDF]

Nanotheranostics
Breast cancer remains a significant global health challenge, with drug resistance and poor bioavailability of chemotherapeutic agents like paclitaxel (PTX) presenting obstacles to effective treatment. This study investigates the potential role of the Solute Carrier Organic Anion Transporter Polypeptide 1A2 (OATP1A2) in PTX transport using computational
Kumar R, Singh G, Akhter Y, Kaithwas G, Agrawal AK, Singh S.   +5 more
europepmc   +3 more sources

Differential Expression Patterns of SLCO Solute Carriers in Human Breast Cancer Cell Lines and Tumour Samples. [PDF]

J Cell Mol Med
ABSTRACT The cellular uptake of nutrients essential for cell growth and survival is facilitated by solute carrier (SLC) transporters. Members of the SLCO subfamily of SLCs mediate the uptake of substrates relevant to breast cancer (BC), including steroid hormones and anticancer drugs.
Telfer-Sutherland R, Page L, Meeson A, Lowes S.   +3 more
europepmc   +2 more sources

Role of Uptake Transporters OAT4, OATP2A1, and OATP1A2 in Human Placental Bio-disposition of Pravastatin [PDF]

Journal of Pharmaceutical Sciences, 2022
Pravastatin is currently under evaluation for prevention of preeclampsia. Factors contributing to placental disposition of pravastatin are important in assessment of potential undesirable fetal effects. The purpose of this study was to identify the uptake transporters that contribute to the placental disposition of pravastatin.
Valentina M, Fokina, Svetlana, Patrikeeva, Xiao-Ming, Wang, Saki, Noguchi, Masatoshi, Tomi, Jörg, König, Mahmoud S, Ahmed, Tatiana, Nanovskaya   +7 more
openaire   +2 more sources

Perinatal Maturation of Drug Transporters and Claudin-5 at the Blood-Brain Barrier. [PDF]

CNS Neurosci Ther
P‐gp expression in the developping human cortex increases with age. In the mouse, gatekeepers of BBB integrity and transport are upregulated: tighter blood–brain barrier, increased claudin 5/Slco1a4/P‐gp expression as well as enhanced P‐gp‐mediated BBB efflux.
Federici L, Cisternino S, Auvity S, Gelot A, Becmeur-Lefebvre M, Favier M, Letort G, Mailly P, Cohen-Salmon M, Boulay AC.   +9 more
europepmc   +2 more sources

Environmental and Genetic Factors Affecting Transport of Imatinib by OATP1A2 [PDF]

Clinical Pharmacology & Therapeutics, 2011
The bioavailability of orally administered imatinib is >90%, although the drug is monocationic under the acidic conditions in the duodenum. In vitro, we found that imatinib is transported by the intestinal uptake carrier organic anion transporting polypeptide (OATP1A2) and that this process is sensitive to pH, rosuvastatin, and genetic variants ...
Eechoute, K., Franke, R. M., Loos, W. J., Scherkenbach, L. A., Boere, I., Verweij, J., Gurney, H., Kim, R. B., Tirona, R. G., Mathijssen, R. H.J., Sparreboom, A.   +10 more
openaire   +3 more sources

Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters

Pharmaceutics, 2021
During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate the major health effects of the disease. These drugs are often applied with analgesics or non-steroid anti-inflammatory compounds, and co-morbid patients may also be ...
Ágnes Telbisz, Csilla Ambrus, Orsolya Mózner, Edit Szabó, György Várady, Éva Bakos, Balázs Sarkadi, Csilla Özvegy-Laczka   +7 more
doaj   +1 more source

P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)

Pharmaceuticals, 2021
Selpercatinib is a targeted, FDA-approved, oral, small-molecule inhibitor for the treatment of rearranged during transfection (RET) proto-oncogene mutation-positive cancer.
Yaogeng Wang, Rolf W. Sparidans, Sander Potters, Rahime Şentürk, Maria C. Lebre, Jos H. Beijnen, Alfred H. Schinkel   +6 more
doaj   +1 more source

Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine

Pharmaceutics, 2020
Herbal drugs are widely used for the auxiliary treatment of diseases. The pharmacokinetics of a drug may be altered when it is coadministered with herbal drugs that can affect drug absorption.
Jung Hwan Ahn, Junhyeong Kim, Naveed Ur Rehman, Hye-Jin Kim, Mi-Jeong Ahn, Hye Jin Chung   +5 more
doaj   +1 more source