Results 11 to 20 of about 1,270 (136)
Correction: OATP1A2 mediates Aβ1-42 transport and may be a novel target for the treatment of Alzheimer’s disease [PDF]
Frontiers in PharmacologyJinhua Wen +4 more
doaj +2 more sources
Molecules, 2021 In this study, we investigated the delivery of synthetic neurosteroids into MCF-7 human breast adenocarcinoma cells via Organic Anionic Transporting Polypeptides (OATPs) (pH 7.4 and 5.5) to identify the structural components required for OATP-mediated ...
Santosh Kumar Adla +5 more
doaj +1 more source
Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer [PDF]
Nanotheranosticsexaly +2 more sources
Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. [PDF]
PLoS ONE, 2013 The current study investigates the potential of estrone-3-sulphate (E3S) as a ligand for targeting Organic Anion Transporting Polypeptides (OATP), a family of membrane associated uptake transporters, for detection and diagnosis of hormone dependent ...
Nilasha Banerjee +5 more
doaj +1 more source
Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters
Pharmaceutics, 2021 During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate the major health effects of the disease. These drugs are often applied with analgesics or non-steroid anti-inflammatory compounds, and co-morbid patients may also be ...
Ágnes Telbisz +7 more
doaj +1 more source
Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine
Pharmaceutics, 2020 Herbal drugs are widely used for the auxiliary treatment of diseases. The pharmacokinetics of a drug may be altered when it is coadministered with herbal drugs that can affect drug absorption.
Jung Hwan Ahn +5 more
doaj +1 more source
Pharmaceuticals, 2021 Selpercatinib is a targeted, FDA-approved, oral, small-molecule inhibitor for the treatment of rearranged during transfection (RET) proto-oncogene mutation-positive cancer.
Yaogeng Wang +6 more
doaj +1 more source
Chinese Medicine, 2020 Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and many ...
Youmna Ali +9 more
doaj +1 more source
Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays. [PDF]
PLoS ONE, 2012 Fluorescent tracer dyes represent an important class of sub-cellular probes and allow the examination of cellular processes in real-time with minimal impact upon these processes.
Samantha Forster +3 more
doaj +1 more source
Using a competitive counterflow assay to identify novel cationic substrates of OATP1B1 and OATP1B3
Frontiers in Physiology, 2022 OATP1B1 and OATP1B3 are two drug transporters that mediate the uptake of multiple endo- and xenobiotics, including many drugs, into human hepatocytes. Numerous inhibitors have been identified, and for some of them, it is not clear whether they are also ...
Regina D. Schnegelberger +3 more
doaj +1 more source