Results 31 to 40 of about 2,031 (173)

Expression of components of the urothelial cholinergic system in bladder and cultivated primary urothelial cells of the pig

BMC Urology, 2019
Background Porcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce up to now. As it has become clear
Dorothea Leonhäuser, Jasmin Kranz, Regina Leidolf, Patrick Arndt, Ulrich Schwantes, Joachim Geyer, Joachim O. Grosse   +6 more
doaj   +1 more source

Inhibition of OATP1B1 by tyrosine kinase inhibitors: In vitro-in vivo correlations [PDF]

, 2014
Background:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1.Methods:The influence of 16 approved
Baker, S.D. (Sharyn), Bruijn, P.J. (Peter) de, Hu, S. (Shuiying), Mathijssen, A.H.J. (Ron), Sparreboom, A. (Alex)   +4 more
core   +1 more source

Interindividual Diversity in Expression of Organic Anion Uptake Transporters in Normal and Cirrhotic Human Liver

Hepatology Communications, 2020
The liver plays an essential role in removing endogenous and exogenous compounds from the circulation. This function is mediated by specific transporters, including members of the family of organic anion transport proteins (OATPs) and the Na ...
Tatsuya Taniguchi, Alana Zanetti‐Yabur, Pijun Wang, Mykhaylo Usyk, Robert D. Burk, Allan W. Wolkoff   +5 more
doaj   +1 more source

Interaction of Rifampin and Darunavir-Ritonavir or Darunavir-Cobicistat In Vitro [PDF]

, 2017
Treatment of HIV-infected patients coinfected with Mycobacterium tuberculosis is challenging due to drug-drug interactions (DDIs) between antiretrovirals (ARVs) and antituberculosis (anti-TB) drugs.
Khoo, Saye, Owen, Andrew, Roberts, Owain, Siccardi, Marco   +3 more
core   +1 more source

Does ethnic variability exist in the systemic exposures of oatp1a2 substrates–fexofenadine in taiwanese?

Indian Journal of Pharmaceutical Sciences, 2015
The aim of this study was to investigate differences in organic anion transporting polypeptide 1A2 activity among the Taiwanese population via an analysis of 3 pharmacokinetic studies completed in a total of 103 healthy male Taiwanese subjects. The pharmacokinetics of fexofenadine was measured as an indicator of organic anion transporting polypeptide ...
Y A, Chen, C H, Juan, K Y, Hsu
openaire   +3 more sources

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy

Haematologica, 2013
Imatinib has so far been the first-choice treatment in chronic myeloid leukemia with excellent results. However, only a proportion of patients achieve major molecular response – hence the need to find biological predictors of outcome to select the ...
Sabrina Angelini, Simona Soverini, Gloria Ravegnini, Matt Barnett, Eleonora Turrini, Mark Thornquist, Fabrizio Pane, Timothy P. Hughes, Deborah L. White, Jerald Radich, Dong Wook Kim, Giuseppe Saglio, Daniela Cilloni, Ilaria Iacobucci, Giovanni Perini, Richard Woodman, Giorgio Cantelli-Forti, Michele Baccarani, Patrizia Hrelia, Giovanni Martinelli   +19 more
doaj   +1 more source

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms [PDF]

Pharmacogenetics and Genomics, 2010
OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and xenobiotics and have been reported to have functional single nucleotide polymorphisms (SNPs).
Ruben C, Hartkoorn, Wai San, Kwan, Victoria, Shallcross, Ammara, Chaikan, Neill, Liptrott, Deirdre, Egan, Enrique Salcedo, Sora, Chloë E, James, Sara, Gibbons, Pat G, Bray, David J, Back, Saye H, Khoo, Andrew, Owen   +12 more
openaire   +2 more sources

Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP)

Pharmaceutics, 2019
Transporters (expressed) at the blood-brain barrier (BBB) can play an essential role in the treatment of brain injury by transporting neuroprotective substance to the central nervous system.
Thamer H Albekairi, Bhuvaneshwar Vaidya, Ronak Patel, Saeideh Nozohouri, Heidi Villalba, Yong Zhang, Yeon Sun Lee, Abraham Al-Ahmad, Thomas J Abbruscato   +8 more
doaj   +1 more source

Marginal increase of sunitinib exposure by grapefruit juice [PDF]

, 2010
PURPOSE: The drug label of sunitinib includes a warning for concomitant use of grapefruit juice (GJ) but clinical evidence for this drug interaction is lacking.
Nielka P. van Erp, Sharyn D. Baker, Anthe S. Zandvliet, Bart A. Ploeger, Margaret den Hollander, Zhaoyuan Chen, Jan den Hartigh, Jacqueline M. C. König-Quartel, Henk-Jan Guchelaar, Hans Gelderblom, RJ Motzer, GD Demetri, VL Goodman, S Faivre, CL Bello, BE Houk, VR Adams, S Shukla, DG Bailey, P Schmiedlin-Ren, EJ Wang, MF Paine, TC Goosen, J Rashid, MF Paine, M Saito, MF Paine, SU Mertens-Talcott, S Reif, OQ Yin, WV Castro De, P Minkin, U Wahlby, DJ Greenblatt, MO Karlsson, JJ Lilja, KE Culm-Merdek, HH Kupferschmidt, H Satoh, GK Dresser, H Glaeser, M Hermann, DG Bailey, VA Eagling, RM Franke, U Fuhr, RB Kim, D Kurnik, D Farkas, ML Veronese, SC Mueller, NP Erp van   +51 more
core   +1 more source