Results 31 to 40 of about 1,270 (136)

Caveolin-dependent internalization of OATP1A2 by PDZK1 and NHERF1.

, 2014
(A) Disruption of the caveolin-dependent pathway impairs OATP1A2-N-flag internalization. HEK-293 cells over-expressing OATP1A2-N-flag were treated with filipin (5 µg/ml) or nystatin (25 µM) for 30 mins, relative to dimethylsulfoxide-treated control.
Jian Zheng (287758), Florence Shin Gee Cheung (550932), Ling Zhu (56356), Michael Murray (361786), Fanfan Zhou (550933), Ting Chan (550931)   +5 more
core   +1 more source

Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS [PDF]

, 2021
Organic anion transporting polypeptides (OATPs) are polyspecific organic anion transporters, which are expressed in the blood-brain barrier, the choroid plexus, and other organs. The physiologic function of OATPs in extrahepatic tissues remains ambiguous.
Vavricka, Stephan, Gao, Bo, Meier, Peter, Stieger, Bruno   +3 more
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Inhibitory Effects of Cranberry Juice and Its Components on Intestinal OATP1A2 and OATP2B1: Identification of Avicularin as a Novel Inhibitor

, 2022
Organic anion-transporting polypeptide (OATP) 1A2 and OATP2B1 mediate the intestinal absorption of drugs. This study aimed to identify fruit juices or fruit juice components that inhibit OATPs and assess the risk of associated food–drug interactions ...
Ayuko Imaoka, Toshiaki Tsuchitani (12173849), Tokio Morita (9661316), Tokio Morita, Toshiaki Tsuchitani, Hiroki Kataoka, Naoya Araki (12173855), Hisakazu Ohtani (9661328), Hiroki Kataoka (12173852), Ayuko Imaoka (9661325), Takeshi Akiyoshi, Kodai Yajima, Takeshi Akiyoshi (9661319), Naoya Araki, Hisakazu Ohtani, Kazuhiro Katayama, Kazuhiro Katayama (764559), Kodai Yajima (9661322)   +17 more
core   +1 more source

Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta [PDF]

, 2020
Special attention is required when pharmacological treatment is indicated for a pregnant woman. P-glycoprotein (MDR1) is a well-known transporter localized in the maternal blood-facing apical membrane of placental syncytiotrophoblast and is considered to
Özvegy-Laczka, Csilla, Hirschmugl, B., Pilarova, V., Bakos, Éva, Sucha, S., Székely, V., Tupova, L.   +6 more
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Association of OATP1A2 with PDZK1 and NHERF1.

, 2014
(A) co-immunoprecipitation of OATP1A2-N-flag and PDZK1-N-myc or NHERF1-N-myc. HEK-293 cells that co-expressed OATP1A2-N-flag and either PDZK1-N-myc or NHERF1-N-myc were lysed and subjected to immunoprecipitation with anti-flag antibody, followed by ...
Jian Zheng (287758), Florence Shin Gee Cheung (550932), Ling Zhu (56356), Michael Murray (361786), Fanfan Zhou (550933), Ting Chan (550931)   +5 more
core   +1 more source

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions [PDF]

, 2012
The biological mechanisms underlying castration resistance of prostate cancer are not fully understood. In the present study, we examined the role of organic anion transporting polypeptides (OATPs) as importers of dehydroepiandrosterone sulfate (DHEAS ...
50248580, 70305100, 27107, 若山, 友彦, 30541742, 30204663, 27108, 27109, Nakanishi, Takeo, Tamai, Ikumi, Yanagihara, Chihiro, Arakawa, Hiroshi, 97, 34, Nishimoto, Tomohiro, 20155237, Kawai, Keiichi, 中西, 猛夫, 玉井, 郁巳, Wakayama, Tomohiko, 246, 126, 川井, 恵一, 40, 溝上, 敦, Mizokami, Atsushi   +25 more
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Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS [PDF]

, 2015
Organic anion transporting polypeptides (OATPs) are polyspecific organic anion transporters, which are expressed in the blood-brain barrier, the choroid plexus, and other organs. The physiologic function of OATPs in extrahepatic tissues remains ambiguous.
Gao, Bo, Vavricka, Stephan R, Meier, Peter J, Stieger, Bruno   +3 more
core   +1 more source

Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters

Frontiers in Pharmacology, 2018
Neurosteroids, comprising pregnane, androstane, and sulfated steroids can alter neuronal excitability through interaction with ligand-gated ion channels and other receptors and have therefore a therapeutic potential in several brain disorders.
Markus Grube, Paul Hagen, Gabriele Jedlitschky   +2 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Identification of centrally active drugs and herbal constituents as substrates of OATP2B1 and OATP1A2 applying the method of competitive counterflow [PDF]

, 2021
For a large number of compounds in clinical use we know that membrane transporter proteins modulate their pharmacokinetic properties. The family of organic anion transporting polypeptides (OATP) facilitates the cellular entry of such compounds.
Schäfer, Anima
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