Results 51 to 60 of about 1,270 (136)

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Stability of OATP1A2 protein in HEK-293 cells in the presence or absence of co-expressed PDZK1 or NHERF1.

, 2014
(A) Western analysis of total cellular expression of OATP1A2-N-flag with or without co-expression of PDZK1 or NHERF1. Top Panel: HEK-293 cells were treated with 5 µg/ml puromycin for 24 and 48 h. Cells were harvested and lysate proteins were separated by
Jian Zheng (287758), Florence Shin Gee Cheung (550932), Ling Zhu (56356), Michael Murray (361786), Fanfan Zhou (550933), Ting Chan (550931)   +5 more
core   +1 more source

Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1 [PDF]

, 2010
International audienceOATP1A2 and OATP2B1 are uptake transporters of the human organic anion transporting polypeptide (OATP) family with a broad substrate spectrum including several endogenous compounds as well as drugs such as the antihistaminic drug ...
Bettina, Balk, Bettina Balk, Siegmund, Werner, Jörg, König, Kathrin Mandery, Glaeser, Hartmut, Mandery, Kathrin, Jörg König, Fromm, Martin F., Ingrid Schmidt, Schmidt, Ingrid, Hartmut Glaeser, Keiser, Markus, Markus Keiser, Martin F. Fromm, Krystyna Bujok, Werner Siegmund, Bujok, Krystyna   +17 more
core   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1499-1511, December 2025.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

The SLCO1A2 Gene, Encoding the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2), is Transactivated by the Vitamin D Receptor (VDR)

, 2012
Organic anion transporting polypeptide 1A2 (OATP1A2; gene symbol SLCO1A2) mediates cellular uptake of a wide range of endogenous substrates, as well as of drugs and xenobiotics. OATP1A2 is expressed in several tissues, including apical membranes of small
Hiller, Christian, Eloranta, Jyrki J, Juttner, Moritz, Kullak-Ublick, Gerd A   +3 more
core   +1 more source

Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short‐Chain Per‐ and Polyfluoroalkyl Substances (PFAS)

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 12, December 2025.
Low‐dose short‐chain PFAS exposures enhance hepatic ABC transporter activity and expression, revealing that environmentally relevant concentrations can reprogram xenobiotic transport pathways and potentially influence drug metabolism, bile acid handling, and lipid homeostasis, highlighting a molecular link between chronic PFAS exposure and altered ...
Gracen E. Collier, Ramon Lavado
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection [PDF]

, 2019
Avian hepatitis E virus (HEV) is the main causative agent of big liver and spleen disease in chickens. Due to the absence of a highly effective cell culture system, there are few reports about the interaction between avian HEV and host cells.
Sun, Zhenzhao, Fan, Mengnan, Huang, Baicheng, Stewart, James P, Sun, Yani, Zhao, Qin, Hiscox, Julian A, Zhou, En-Min, Chen, Yiyang, Ji, Pinpin, Zhang, Beibei, Liu, Baoyuan, Nan, Yuchen, Li, Huixia   +13 more
core   +1 more source

Die Rolle von Organic-Anion-Transporting-Polypeptides (OATPs) in der Wirkung von Lokalanästhetika [PDF]

, 2019
Lokalanästhetika unterbrechen via Blockade von Natriumkanälen die Fortleitung von Aktionspotentialen entlang neuronaler Strukturen. [1] Wie Lokalanästhetika an ihren Effektort am Natriumkanal gelangen ist noch weitgehend ungeklärt.
Antener, Enrica Barbara
core   +2 more sources

Altered transport function and expression of OATP1A2 in HEK-293 cells in the presence and absence of co-transfected PDZK1 and NHERF1.

, 2014
(A) Transport of 300 nM [3H] E3S in OATP1A2-transfected HEK-293 cells with or without co-expressed PDZK1 or NHERF1 at 37°C. Values are means ± S.E. (n = 3).
Jian Zheng (287758), Florence Shin Gee Cheung (550932), Ling Zhu (56356), Michael Murray (361786), Fanfan Zhou (550933), Ting Chan (550931)   +5 more
core   +1 more source