Results 51 to 60 of about 2,031 (173)

Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties [PDF]

, 2018
The organic anion transporting polypeptides (rodents: Oatps, human: OATPs) form a superfamily of sodium-independent transport systems that mediate the transmembrane transport of a wide range of amphipathic endogenous and exogenous organic compounds ...
Hagenbuch, Bruno, Meier, Peter
core  

Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells [PDF]

, 2015
International audienceTiO2 microparticles are widely used in food products, where they are added as a white food colouring agent. This food additive contains a significant amount of nanoscale particles; still the impact of TiO2 nanoparticles (TiO2-NPs ...
Barreau, Frédérick, Brun, Emilie, Carapito, Christine, Carrière, Marie, Desvergne, Caroline, Dorier, Marie, Herlin, Nathalie, Pernet-Gallay, Karin, Rabilloud, Thierry, Veronesi, Giulia   +9 more
core   +3 more sources

Obesity and Natural Products: Mechanisms, Therapeutic Potential, and Future Directions

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Natural products such as EGCG, berberine, curcumin, and capsaicin modulate key metabolic pathways including AMPK activation, adipogenesis inhibition, and inflammatory signaling. While clinical trials demonstrate modest benefits on body weight and metabolic parameters, translational challenges related to bioavailability, dose feasibility, and regulatory
Ohoud M. Marie, Abdelghafar Abu‐Elsaoud   +1 more
wiley   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Thyroid hormones and the central nervous system of mammals (Review) [PDF]

, 2008
. The thyroid hormones (THs) L-thyroxine (T4) and L-triiodothyronine (T3) have a profound influence on the development and maturation of the mammalian brain, both before and after birth.
DI LIEGRO, Italia
core   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1499-1511, December 2025.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1

Journal of Pharmaceutical Sciences
Organic anion transporting polypeptide (OATP)1A2 and OATP2B1 have potential N-glycosylation sites, but their influence remains unclear. This study aimed to identify the N-glycosylation sites of OATP1A2/2B1 and investigate their impact on the expression and function of OATP1A2/2B1.
Hiroki Kataoka, Takeshi Akiyoshi, Yasuo Uchida, Ayuko Imaoka, Tetsuya Terasaki, Hisakazu Ohtani   +5 more
openaire   +4 more sources

Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all‐trans‐retinol in human retinal pigmented epithelial cells [PDF]

British Journal of Pharmacology, 2015
Background and PurposeVision depends on retinoid exchange between the retinal pigment epithelium (RPE) and photoreceptors. Defects in any step of the canonical visual cycle can lead to retinal degenerations. All‐trans‐retinol (atROL) plays an important role in visual signal transduction.
Ting, Chan, Ling, Zhu, Michele C, Madigan, Ke, Wang, Weiyong, Shen, Mark C, Gillies, Fanfan, Zhou   +6 more
openaire   +2 more sources

Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short‐Chain Per‐ and Polyfluoroalkyl Substances (PFAS)

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 12, December 2025.
Low‐dose short‐chain PFAS exposures enhance hepatic ABC transporter activity and expression, revealing that environmentally relevant concentrations can reprogram xenobiotic transport pathways and potentially influence drug metabolism, bile acid handling, and lipid homeostasis, highlighting a molecular link between chronic PFAS exposure and altered ...
Gracen E. Collier, Ramon Lavado
wiley   +1 more source