Results 41 to 50 of about 1,270 (136)
The Journal of Physiology, EarlyView.Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade +13 more
wiley +1 more source
Primary and secondary thyroid hormone transporters
Thyroid Research, 2011 Thyroid hormones (TH) are essential for the development of the human brain, growth and cellular metabolism. Investigation of TH transporters became one of the emerging fields in thyroid research after the discovery of inactivating mutations in the ...
Kinne Anita, Schülein Ralf, Krause Gerd
doaj +1 more source
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel [PDF]
, 2015 Organic anion transporting polypeptides (human: OATPs and mouse: Oatps) are uptake transporters with important roles in drug pharmacokinetics and toxicity. We aimed to study the in vivo impact of mouse and human OATP1A/1B transporters on docetaxel plasma
van Esch, Anita +9 more
core +1 more source
ChemMedChem, Volume 21, Issue 8, 28 April 2026.Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo +8 more
wiley +1 more source
Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery
Advanced Science, Volume 13, Issue 20, 9 April 2026.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
OATP1A2 expression in MCF-7 (A) and MDA-MB-231 (B) xenograft sections.
, 2013 A statistically significant ...
Humphrey Fonge (414503) +5 more
core +1 more source
Obesity and Natural Products: Mechanisms, Therapeutic Potential, and Future Directions
Food Science &Nutrition, Volume 14, Issue 3, March 2026.Natural products such as EGCG, berberine, curcumin, and capsaicin modulate key metabolic pathways including AMPK activation, adipogenesis inhibition, and inflammatory signaling. While clinical trials demonstrate modest benefits on body weight and metabolic parameters, translational challenges related to bioavailability, dose feasibility, and regulatory
Ohoud M. Marie +1 more
wiley +1 more source
, 2014 (A) OATP1A2-N-flag internalization was undertaken as described under “Materials and Methods,” followed by Western blotting with an anti-Flag antibody; a representative of 3 separate experiments was shown.
Jian Zheng (287758) +5 more
core +1 more source
Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia [PDF]
, 2011 The purpose of this study was to explore the role of the organic-anion transporting polypeptide (OATP) 1A2 that is encoded by SLCO1A2, in the cellular uptake of the BCR-ABL tyrosine kinase inhibitor imatinib, and the relationship between SLCO1A2 ...
111932 +39 more
core +2 more sources
Organic anion transporters and their influence on the toxicity of β-lactam antibiotics
Безопасность и риск фармакотерапии, 2018 This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev +5 more
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