Results 21 to 30 of about 1,270 (136)
Microcystins: Potent xenobiotics [PDF]
Archive of Oncology, 2011 Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics.
Ilić Maja +2 more
doaj +1 more source
ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium--Effects of Prochloraz. [PDF]
PLoS ONE, 2016 Some chemicals are ligands to efflux transporters which may result in high concentrations in milk. Limited knowledge is available on the influence of maternal exposure to chemicals on the expression and function of transporters in the lactating mammary ...
Yagmur Yagdiran +3 more
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Characterization of the membrane transporter OATP1A2 activity towards different classes of drugs [PDF]
, 2016 Les transporteurs membranaires sont des éléments importants dans le devenir, l’efficacité, et la toxicité du médicament. Ils influencent la pharmacocinétique et la pharmacodynamie de ces derniers.
Lu, Jennifer
core +1 more source
BMC Urology, 2019 Background Porcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce up to now. As it has become clear
Dorothea Leonhäuser +6 more
doaj +1 more source
Hepatology Communications, 2020 The liver plays an essential role in removing endogenous and exogenous compounds from the circulation. This function is mediated by specific transporters, including members of the family of organic anion transport proteins (OATPs) and the Na ...
Tatsuya Taniguchi +5 more
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Haematologica, 2013 Imatinib has so far been the first-choice treatment in chronic myeloid leukemia with excellent results. However, only a proportion of patients achieve major molecular response – hence the need to find biological predictors of outcome to select the ...
Sabrina Angelini +19 more
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Expression and Functional Contribution of Different Organic Cation Transporters to the Cellular Uptake of Doxorubicin into Human Breast Cancer and Cardiac Tissue [PDF]
, 2021 Doxorubicin is a frequently used anticancer drug to treat many types of tumors, such as breast cancer or bronchial carcinoma. The clinical use of doxorubicin is limited by its poorly predictable cardiotoxicity, the reasons of which are so far not fully ...
Susanne Csader +7 more
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Pharmaceutics, 2019 Transporters (expressed) at the blood-brain barrier (BBB) can play an essential role in the treatment of brain injury by transporting neuroprotective substance to the central nervous system.
Thamer H Albekairi +8 more
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Clathrin-dependent internalization of OATP1A2 by PDZK1 and NHERF1.
, 2014 (A) Disruption of the clathrin-dependent pathway impairs OATP1A2-N-flag internalization. HEK-293 cells over-expressing OATP1A2-N-flag were treated with K+ depletion buffer or 10 mM acetic acid for 30 mins, relative to PBS-treated control. Internalization
Jian Zheng (287758) +5 more
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Endoxifen-glucuronide and 4-hydroxy-tamoxifen glucuronide are substrates of OATP1A2
ASPET DiscoveryTamoxifen is a widely prescribed antiestrogen for breast cancer therapy that undergoes P450-mediated formation of the active metabolites 4-hydroxy-tamoxifen (4-OH-tamoxifen) and endoxifen prior to glucuronidation. Organic anion-transporting polypeptides (
Michelle K. Wong +3 more
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