Results 21 to 30 of about 2,031 (173)
Chinese Medicine, 2020 Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and many ...
Youmna Ali +9 more
doaj +1 more source
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel. [PDF]
International journal of cancer, 2014 Organic anion transporting polypeptides (human: OATPs and mouse: Oatps) are uptake transporters with important roles in drug pharmacokinetics and toxicity. We aimed to study the in vivo impact of mouse and human OATP1A/1B transporters on docetaxel plasma clearance and liver and intestinal uptake.
Iusuf, Dilek +7 more
openaire +4 more sources
Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays. [PDF]
PLoS ONE, 2012 Fluorescent tracer dyes represent an important class of sub-cellular probes and allow the examination of cellular processes in real-time with minimal impact upon these processes.
Samantha Forster +3 more
doaj +1 more source
Using a competitive counterflow assay to identify novel cationic substrates of OATP1B1 and OATP1B3
Frontiers in Physiology, 2022 OATP1B1 and OATP1B3 are two drug transporters that mediate the uptake of multiple endo- and xenobiotics, including many drugs, into human hepatocytes. Numerous inhibitors have been identified, and for some of them, it is not clear whether they are also ...
Regina D. Schnegelberger +3 more
doaj +1 more source
Tricyclic compounds inhibit the OATP1A2 transporter
The FASEB Journal, 2013 Background OATP1A2 is a membrane transporter potentially involved in the absorption of various drugs. Previous data demonstrated that the uptake of rosuvastatin through OATP1A2 can be inhibited by several β‐blockers, where carvedilol is the most potent inhibitor.
Jennifer Lu +4 more
openaire +1 more source
Microcystins: Potent xenobiotics [PDF]
Archive of Oncology, 2011 Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics.
Ilić Maja +2 more
doaj +1 more source
The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs [PDF]
, 2009 Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives ...
Sarah Shugarts +161 more
core +3 more sources
ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium--Effects of Prochloraz. [PDF]
PLoS ONE, 2016 Some chemicals are ligands to efflux transporters which may result in high concentrations in milk. Limited knowledge is available on the influence of maternal exposure to chemicals on the expression and function of transporters in the lactating mammary ...
Yagmur Yagdiran +3 more
doaj +1 more source
The importance of steroid uptake and intracrine action in endometrial and ovarian cancers [PDF]
, 2017 Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Laczka, Csilla +2 more
core +2 more sources
Pre‐systemic fexofenadine drug‐drug interactions at OATP1A2
The FASEB Journal, 2011 Fexofenadine (Fex) disposition is controlled by transporters, however there is uncertainty regarding the roles of specific transporters in Fex absorption. We previously tested a probe drug cocktail containing Fex, buspirone (Busp), caffeine, dextromethorphan (DM) and losartan (Los) for the measurement of transporter and CYP ...
Colleen Ann Flynn +2 more
openaire +1 more source