Results 61 to 70 of about 1,270 (136)
Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 5, Page 345-358, September 2025.ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste +4 more
wiley +1 more source
The effects of N-glycosylation on the expression and transport activity of OATP1A2 and OATP2B1
Organic anion transporting polypeptide (OATP)1A2 and OATP2B1 have potential N-glycosylation sites, but their influence remains unclear. This study aimed to identify the N-glycosylation sites of OATP1A2/2B1 and investigate their impact on the expression ...
Ohtani, Hisakazu +5 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2028-2044, July 2025.Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2057-2069, July 2025.Abstract Aims In a large cohort of hospitalized patients, previously validated physiologically based pharmacokinetic (PBPK)‐based models for apixaban and rivaroxaban are being assessed for their performance in predicting individual pharmacokinetics, aiming to identify patients at high risk of under‐ or overdosing based on demographic, physiological and
Frédéric Gaspar +12 more
wiley +1 more source
New rational for chemotherapy targeting transporters expressed in cancer stem cells [PDF]
, 2016 栄養要求性の変化に応答する生理的輸送体とがん増殖・進展との関係が検討された。アンドロゲン不含培地で培養されたヒト前立腺癌由来LNCaP細胞 において、dehydroepiandrosterone sulfate（DHEAS）を認識する有機アニオン輸送体OATP1A2の発現が増加した。OATP1A2発現抑制により、細胞増殖、コロニー形成および浸潤能に対するDHEASの効果は有意に減少した。さらに、アンドロゲン不含培地においてOATP1A2に輸送される抗がん剤メソトレキセートに対する感受性が増加したため ...
246, 中西, 猛夫, 30541742
core +1 more source
, 2005 Organic anion-transporting polypeptide 1A2 (OATP1A2) is a drug uptake transporter known for broad substrate specificity, including many drugs in clinical use.
Moeckel, Gilbert W. +7 more
core +1 more source
A Narrative Review on the Effect of Valproic Acid on the Placenta
Birth Defects Research, Volume 117, Issue 4, April 2025.ABSTRACT Background Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug with well‐established teratogenic risks when taken during pregnancy. While its harmful effects on fetal development are well known, less attention has been given to its impact on placental development and function, despite the placenta's critical role in pregnancy ...
Lauren T. L. Brown +2 more
wiley +1 more source
, 2016 Important antimalarial drugs, including quinolines, act against blood schizonts by interfering with hemoglobin metabolism. To reach their site of action, these compounds have to cross the plasma membrane of red blood cells (RBCs).
Kroemer, Heyo K. +6 more
core +1 more source
Interaction of imatinib with human organic ion carriers [PDF]
, 2008 Purpose: The activity of imatinib in leukemia has recently been linked with expression of the organic cation transporter 1 (OCT1) gene SLC22A1. Here, we characterized the contribution of solute carriers to imatinib transport in an effort to further ...
Filipski, K.K. (Kelly) +7 more
core +1 more source
FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS [PDF]
, 2011 Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity.
Flynn, Colleen A.
core +1 more source