Results 61 to 70 of about 2,031 (173)

Is a low level of free thyroxine in the maternal circulation associated with altered endothelial function in gestational diabetes? [PDF]

, 2014
Synthesis of thyroid hormones, thyroxine (T4) and tri-iodothyronine (T3), in the human fetus starts from 17 to 19th weeks of gestation. Despite the majority of normal pregnant women reaching adequate levels of circulating thyroid hormones, in some cases,
Escudero, Carlos, Guzman-Gutierrez, Enrique, Leiva, Andrea, Sobrevia, Luis, Veas, Carlos   +4 more
core   +1 more source

Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters [PDF]

, 2020
Quercetin is a flavonoid, its glycosides and aglycone are found in significant amounts in several plants and dietary supplements. Because of the high presystemic biotransformation of quercetin, mainly its conjugates appear in circulation.
Fliszár-Nyúl, Eszter, Kuffa, Katalin, Laczka, Csilla, Mohos, Violetta Karolin, Needs, Paul W., Poór, Miklós, Ungvári, Orsolya   +6 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Organic anion transporters and their influence on the toxicity of β-lactam antibiotics

Безопасность и риск фармакотерапии, 2018
This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, N. D. Bunyatyan, E. V. Shikh, R. E. Kazakov   +5 more
doaj  

Hidratación e ingredientes químicos en el deporte: seguridad alimentaria en el contexto europeo [PDF]

, 2015
Before, during and after physical activity, hydration is a limiting factor in athletic performance. Therefore, adequate hydration provides benefits for health and performance of athletes.
Gil-Izquierdo, Ángel, Gómez-Zorita, Saioa, Martínez Sanz, José Miguel, Medina Escudero, Sonia, Soriano, José M., Urdampilleta, Aritz   +5 more
core   +2 more sources

Interações frutas/vegetais: fármaco com importância clínica [PDF]

, 2014
Trabalho Complementar apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de licenciada em Ciências da NutriçãoIntrodução: A ação profilática das frutas e vegetais em inúmeras doenças crónicas, como diabetes ...
Tavares, Cíntia Dalila Covêlo Sequeira
core  

Kernel-Based Feature Selection Techniques for Transport Proteins Based on Star Graph Topological Indices [PDF]

, 2013
[Abstract] The transport of the molecules inside cells is a very important topic, especially in Drug Metabolism. The experimental testing of the new proteins for the transporter molecular function is expensive and inefficient due to the large amount of ...
Dorado, Julián, Fernández-Lozano, Carlos, Gestal, M., Munteanu, Cristian-Robert, Pedreira Souto, Nieves, Postelnicu, Lucian   +5 more
core   +2 more sources

Is Rifampin (Rifampicin) Essential for the Treatment of Rhodococcus equi Infections in Foals? A Critical Review of the Role of Rifampin

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 5, Page 345-358, September 2025.
ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste, Niels Christian Kyvsgaard, Mohamed Omar Ahmed, Peter Damborg, Patricia M. Dowling   +4 more
wiley   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2028-2044, July 2025.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Virtual twin approach using physiologically based pharmacokinetic modelling in hospitalized patients treated with apixaban or rivaroxaban

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2057-2069, July 2025.
Abstract Aims In a large cohort of hospitalized patients, previously validated physiologically based pharmacokinetic (PBPK)‐based models for apixaban and rivaroxaban are being assessed for their performance in predicting individual pharmacokinetics, aiming to identify patients at high risk of under‐ or overdosing based on demographic, physiological and
Frédéric Gaspar, Jean Terrier, Celestin Jacot‐Descombes, Pauline Gosselin, Valentine Ardoino, Camille Lenoir, Victoria Rollason, Chantal Csajka, Caroline F. Samer, Pierre Fontana, Youssef Daali, Jean‐Luc Reny, for the OptimAT study group   +12 more
wiley   +1 more source