Results 71 to 80 of about 2,031 (173)

A Narrative Review on the Effect of Valproic Acid on the Placenta

Birth Defects Research, Volume 117, Issue 4, April 2025.
ABSTRACT Background Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug with well‐established teratogenic risks when taken during pregnancy. While its harmful effects on fetal development are well known, less attention has been given to its impact on placental development and function, despite the placenta's critical role in pregnancy ...
Lauren T. L. Brown, Delaine Pereira, Louise M. Winn   +2 more
wiley   +1 more source

Pregnenolone Sulfate Permeation at the Blood–Brain Barrier is Independent of OATP2B1—In Vivo and In Vitro Insights

Biopharmaceutics &Drug Disposition, Volume 46, Issue 1, Page 33-46, February 2025.
In our study we report that OATP2B1 does not mediate pregnenolone sulfate transport across the blood–brain barrier in rats and in a human cell model, thus suggesting alternative mechanisms involved in pregnenolone sulfate brain uptake. ABSTRACT Sulfated steroids such as pregnenolone sulfate (PregS) are important for neuronal development and cognitive ...
Valerio Taggi, Anima M. Schäfer, Stefan Oswald, Jonny Hanna Kinzi, Isabell Seibert, Alaa Al‐Khatib, Henriette E. Meyer zu Schwabedissen   +6 more
wiley   +1 more source

Effects of Green Tea and Epigallocatechin Gallate on the Transport of Folic Acid by the Proton‐Coupled Folate Transporter

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Folic acid (FA) is a water‐soluble vitamin absorbed in the small intestine through the proton‐coupled folate transporter (PCFT) when taken orally. In this study, we investigated the effect of green tea on PCFT‐mediated FA transport. Green tea inhibited FA uptake by PCFT in a concentration‐dependent manner, with an IC50 value of 6.1%.
Tomoya Narawa, Ayaka Furuta, Hinano Tanaka, Tomoo Itoh, Anupama Bose   +4 more
wiley   +1 more source

Data from Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

, 2023
<div>Abstract<p><b>Purpose:</b> Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and toxicokinetics. We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1A2 transporters on the <i>in vivo</i> ...
Alfred H. Schinkel, Kathryn E. Kenworthy, Els Wagenaar, Anita van Esch, Evita van de Steeg   +4 more
openaire   +1 more source

Combating Methotrexate Resistance in Cancer Treatment: A Review on Navigating Pathways and Enhancing Its Efficacy With Fat‐Soluble Vitamins

Scientifica, Volume 2025, Issue 1, 2025.
Methotrexate (MTX), a potent analogue and antagonist of folic acid, is a first‐line treatment for rheumatoid arthritis, IBD and cancer. The development of MTX resistance contributes to the reduced efficacy and development of adverse reactions, forcing clinicians to withdraw treatment early.
Muhsina Kakkadath, Disha Naidu, S. K. Kanthlal, Khan Sharun, Raghuram Kandimalla   +4 more
wiley   +1 more source

Supplemental Figure 2 from Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

, 2023
<p>PDF file - 159K,Immunohistochemical staining of OATP1B3 in kidneys of humanized transgenic OATP1B3 mice</p>
Alfred H. Schinkel, Kathryn E. Kenworthy, Els Wagenaar, Anita van Esch, Evita van de Steeg   +4 more
openaire   +1 more source

A literature review of drug transport mechanisms during lactation

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 11, Page 1870-1880, November 2024.
Abstract Despite the benefits of breastfeeding, lactating mothers who take prescribed medications may discontinue breastfeeding due to concerns associated with infant drug exposure in breastmilk. Consolidating the current knowledge of drug transport to breastmilk may inform understanding of the safety of medication use during lactation. This literature
Christine Gong, Lynn N. Bertagnolli, David W. Boulton, Paola Coppola   +3 more
wiley   +1 more source

Supplemental Methods from Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

, 2023
<p>PDF file - 86K,Descriptive RT-PCR data about the expression of other transporter proteins in livers of knockout and humanized transgenic OATP mice</p>
Alfred H. Schinkel, Kathryn E. Kenworthy, Els Wagenaar, Anita van Esch, Evita van de Steeg   +4 more
openaire   +1 more source

A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 11, Page 1856-1869, November 2024.
Abstract Breastfeeding is the most complete nutritional method of feeding infants, but several impediments affect the decision to breastfeed, including questions of drug safety for medications needed during lactation. Despite recent FDA guidance, few labels provide clear dosing advice during lactation.
Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami‐Hodjegan, Brian J. Schmidt, Lu Gaohua, Aleksandra Galetin   +7 more
wiley   +1 more source

Supplemental Figure 1 from Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

, 2023
<p>PDF file - 63K, Ponceau S staining confirming equal protein loading in the Western blot analyses presented in Figure 1</p>
Alfred H. Schinkel, Kathryn E. Kenworthy, Els Wagenaar, Anita van Esch, Evita van de Steeg   +4 more
openaire   +1 more source