Results 71 to 80 of about 1,270 (136)

Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans

, 2007
The goals of this study were to assess the extent of human intestinal drug transporter expression, determine the subcellular localization of the drug uptake transporter OATP1A2, and then to assess the effect of grapefruit juice consumption on OATP1A2 ...
Lee, W., Gregor, J. C., Jolicoeur, E., U I Schwarz, Dresser, G. K., Leake, B. F., E Jolicoeur, R B Kim, McGrath, J. S., H Glaeser, R G Tirona, G K Dresser, Schwarz, U. I., Kim, R. B., Tirona, R. G., D G Bailey, W Lee, Bailey, D. G., J S McGrath, B F Leake, Glaeser, H., J C Gregor   +21 more
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Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity

This study investigated the impact of genetic variations in organic anion transporting polypeptides (OATPs) 1A2 and 2B1 on their transport activity at pH 6.3 and 7.4 by using HEK293 cells expressing OATP variants, focusing on stoichiometric transport ...
Morita, Tokio, Ohtani, Hisakazu, Imaoka, Ayuko, Akiyoshi, Takeshi, Poso, Antti, Medarametla, Prasanthi, Yajima, Kodai, Kataoka, Hiroki, Terasaki, Tetsuya, Tonduru, Arun Kumar, Katayama, Kazuhiro, Uchida, Yasuo   +11 more
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Untersuchungen zur Expression und Funktion von OATP-Transportern in Blutzellen und der Blut-Hirn-Schranke [PDF]

, 2016
Aus pharmakologischer Sicht sind unter den Aufnahmetransportern Vertreter der organic anion transporting polypeptide-Familie (OATPs) von besonderem Interesse.
Hubeny, Andrea
core   +1 more source

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms

OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs.
Owen, A, Chaikan, A, Sora, ES, Bray, PG, Kwan, WS, Hartkoorn, RC, Back, DJ, Shallcross, V, Liptrott, N, Egan, D, James, C, Khoo, SH, Gibbons, S   +12 more
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Untersuchungen zum OATP- abhängigen Transport der Opioide Fentanyl und Sufentanil sowie die Generierung von stabil transfizierten Zelllinien mithilfe des Flp-In™ Systems [PDF]

In der Klinik wird eine inter- und intraindividuelle Variabilität in Wirkung und Nebenwirkung von Opioiden beobachtet [5,6]. Ursächlich hierfür könnte unter anderem eine individuelle Ausstattung mit Transportproteinen sein, welche pharmakologische ...
Hofmann, Corinna
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Effect of carbon ion irradiation on drug transporters organic anion transporting polypeptides in Breast Cancer Cells

, 2017
Organic anion transporting polypeptides (OATPs) are a family of membrane uptake transporters that play important roles in absorption, distribution, metabolism and excretion of wide ranges of endogenous and exogenous compounds.
Zhou, Chao, Konishi, Teruaki, Xiao, Yunpeng, 494644, 494643, 494642, Hong, Mei, Fang, Zihui, 小西 輝昭, Rong, Yang, 494648, 494647, 494646, 494645   +13 more
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Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

, 2011
We describe a mechanistic investigation of drug–drug interaction between aliskiren and grapefruit juice in healthy subjects. Twenty-eight subjects received an oral dose of aliskiren 300 mg (highest recommended clinical dose) with 300 mL water or ...
Zhao, Sally, Hariry, Sam, Alexander, Natalya, Hanna, Imad, Rebello, Sam, Jarugula, Venkateswar, Vapurcuyan, Arpine, Dahlke, Marion   +7 more
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Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.

, 2011
International audienceThe goal of this study was to assess the interaction of the mTOR inhibitors (ImTORs) sirolimus and everolimus with the human organic anion-transporting polypeptides (OATPs) expressed in hepatocytes and enterocytes by conducting ...
Fabien Lamoureux, Giacomini, Kathleen M, Kathleen M. Giacomini, Picard, Nicolas, Levoir, Laure, Sook Wah Yee, Lamoureux, Fabien, Laure Levoir, Marquet, Pierre, Yee, Sook Wah, Nicolas Picard, Pierre Marquet   +11 more
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Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. [PDF]

Mol Pharmacol, 2023
Sun A, Hagenbuch B, Kelly EJ, Wang J.
europepmc   +1 more source

Expression of Drug Transporters and Drug Metabolizing Enzymes in the Bladder Urothelium in Man and Affinity of the Bladder Spasmolytic Trospium Chloride to Transporters Likely Involved in Its Pharmacokinetics

, 2016
The cationic, water-soluble quaternary trospium chloride (TC) is incompletely absorbed from the gut and undergoes wide distribution but does not pass the blood–brain barrier. It is secreted by the kidneys, liver, and intestine.
Tanja Graf (1695121), Jia Jia (448088), Werner Siegmund (369018), Uwe Zimmermann (214606), Kathrin Rodewald (1695115), Stefan Oswald (1695106), Ulrich Schwantes (1695112), Markus Keiser (1695118), Maria Bexten (1695109), Markus Grube (369015), Oliver Zolk (526793)   +10 more
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