Results 111 to 120 of about 1,339,496 (303)
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
General practitioners’ beliefs about obesity and their decision to treat [PDF]
, 2013 The current study explored the relationships between GPs‟ beliefs about the cause of obesity and treatment choices. Participants (n = 81) responded to two sets of materials; vignettes featuring obese patients in which the grade and cause of obesity were ...
Hartley, Nicholas Terry
core
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout
Biology of Sex DifferencesBackground Brain-derived neurotrophic factor (BDNF) is highly expressed in the hypothalamus where it exerts regulatory functions over neurogenesis, reproduction, energy balance, and metabolism.
Dayana Cabral-da-Silva +7 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Genotype subtyping approach to identify unnoticed variants in diseases from GWAS data
BioData MiningGenome-wide association studies (GWAS) are vital for investigating single-nucleotide polymorphisms (SNPs) in diseases. Comparisons of detected SNPs for the same disease between populations often reveal gaps, which are attributed to factors such as ...
Debora Garza-Hernandez +2 more
doaj +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Determinants of binge eating symptoms in children with overweight and obesity"
, 2016 Background: Binge eating symptoms may be early signs of an eating disorder in children with overweight and obesity. Methods: We examined the prevalence and multi-level determinants of three binge eating symptoms: (1) sneaking, hiding, or hoarding food; (
Horan, Christine +6 more
core
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Eating and Weight DisordersPurpose Bariatric surgery (BS), an effective treatment for severe obesity and its comorbidities, may result in micronutrient and vitamin deficiencies.
Alessio Basolo +20 more
doaj +1 more source