Overview of the Pathophysiological Implications of Organotins on the Endocrine System
Frontiers in Endocrinology, 2018 Organotins (OTs) are pollutants that are used widely by industry as disinfectants, pesticides, and most frequently as biocides in antifouling paints.
Vinicius Bermond Marques +3 more
doaj +1 more source
Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47 [PDF]
, 2014 Recent studies suggest that exposure to endocrine-disrupting compounds (EDCs) may play a role in the development of obesity. EDCs such as the flame retardant 2,2′,4,4′-tetrabrominated diphenyl ether (BDE-47) have been shown to enhance adipocyte ...
Blumberg, B +6 more
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Expanding The Temporal Dimensions Of Developmental Biology: The Role Of Environmental Agents In Establishing Adult-Onset Phenotypes [PDF]
, 2011 Developmental biology is expanding into several new areas. One new area of study concerns the production of adult-onset phenotypes by exposure of the fetus or neonate to environmental agents.
Gilbert, Scott F.
core +2 more sources
Screening obesogens in aquatic model organisms [PDF]
, 2017 Ana Maria Ferreira Capitão
core +3 more sources
Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism [PDF]
, 2014 Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) with harmful effects in animals and humans. Although PCB 153 is one of the most abundant among PCBs detected in animal tissues, its mechanism of toxicity is not well ...
Anders Goksøyr +4 more
core +1 more source
Environmental Obesogens: Mechanisms and Controversies [PDF]
Annual Review of Pharmacology and Toxicology, 2019 Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure.
Heindel, Jerrold J, Blumberg, Bruce
openaire +4 more sources
Los Disruptores Endocrinos Como Obesógenos Ambientales: Efectos en Proteínas Adipogénicas Clave [PDF]
, 2022 Los disruptores endocrinos (EDC) son compuestos químicos exógenos de origen sintético o natural que interfieren en las funciones hormonales. Se estima que más de 1000 compuestos químicos presentes en el medio ambiente poseen una posible actividad ...
Ahumada-Solórzano, Marisela +7 more
core +2 more sources
The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease [PDF]
, 2015 Background Non alcoholic fatty liver disease (NAFLD) results from alteration in lipid synthesis and elimination mechanisms such as very-low density lipoprotein (VLDL) production and de novo lipogenesis. Persistent organic pollutants (POPs)
Caroline Lefebvre +2 more
core +1 more source
Minireview: PPARγ as the target of obesogens [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 The peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis and is medically important for its connections to obesity and the treatment of type II diabetes. Activation of this receptor by certain natural or xenobiotic compounds has been shown to stimulate adipogenesis in vitro and in vivo.
Amanda, Janesick, Bruce, Blumberg
openaire +2 more sources
Obesity Reviews, EarlyView.ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye +6 more
wiley +1 more source