Results 41 to 50 of about 781 (170)

Obesogens: molecular signaling pathways in fish

Frontiers in Marine Science, 2015
* santos@ciimar.up.pt; filipe.castro@ciimar.up.pt In mammals, improper control of lipid metabolism may result in serious health problems such as obesity, increased risk of coronary disease, diabetes and related problems.
Miguel Machado Santos, Mónica Marques, Luis Filipe, C Castro   +2 more
doaj   +1 more source

Subacute Exposure to Aldrin, Endosulfan and Lindane Differentially Alters Metabolic and Inflammatory Gene Expression in White and Brown Adipose Tissue of Male Rats

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Persistent organic pollutants such as organochlorine pesticides (OCPs) have been implicated in obesity and metabolic dysfunction. As they bioaccumulate in adipose tissue, OCPs may act as obesogens, but in vivo evidence for aldrin, endosulfan and lindane is limited.
Nada Abdelhamid Mohamed Boujanah, Cihan Suleyman Erdogan, Engin Sumer, Cansu Yakin, Bayram Yilmaz   +4 more
wiley   +1 more source

Protocols for the development of the guidance on the risk assessment of PPP to non‐target arthropods, in‐soil organisms and non‐target terrestrial plants

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The present document defines the problem formulation, evidence needs and methodological approach agreed by the Environmental Risk Assessment Working Group and the EFSA Panel on Plant Protection Products and their Residues for the Tier 1 risk assessment of the terrestrial ecotoxicology guidance document.
European Food Safety Authority (EFSA), Pauline Adriaanse, Gertie Arts, Sandra Boline Lassen, Mark Brown, Pierre‐Francois Chaton, Matthias Fürst, Brecht Ingels, Silvia Pieper, Maj Rundlöf, Jose Paulo Sousa, Renske van Eekelen, Fernando Alvarez, Maria Arena, Gabriella Fait, Alessio Ippolito, Alberto Linguadoca, Laura Padovani, Csaba Szentes, Domenica Auteri   +19 more
wiley   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, Volume 46, Issue 6, Page 2003-2018, June 2026.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Addressing chemically-induced obesogenic metabolic disruption: selection of chemicals for in vitro human PPARα, PPARγ transactivation, and adipogenesis test methods

Frontiers in Endocrinology
Whilst western diet and sedentary lifestyles heavily contribute to the global obesity epidemic, it is likely that chemical exposure may also contribute.
Eren Ozcagli, Barbara Kubickova, Miriam N. Jacobs   +2 more
doaj   +1 more source

Potentilla rugulosa Nakai Extract Attenuates Bisphenol A-, S- and F-Induced ROS Production and Differentiation of 3T3-L1 Preadipocytes in the Absence of Dexamethasone

Antioxidants, 2020
Endocrine disrupting chemicals (EDCs) disrupt the physiological metabolism, thus playing an important role in the development of obesity. EDCs, the so-called ‘obesogens’, might predispose some individuals to gain weight.
Sun-Il Choi, Jong Seok Lee, Sarah Lee, Wan-Sup Sim, Young-Cheul Kim, Ok-Hwan Lee   +5 more
doaj   +1 more source

The Mammalian "Obesogen" Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish. [PDF]

PLoS ONE, 2015
Recent findings indicate that different Endocrine Disrupting Chemicals (EDCs) interfere with lipid metabolic pathways in mammals and promote fat accumulation, a previously unknown site of action for these compounds.
Angeliki Lyssimachou, Joana G Santos, Ana André, Joana Soares, Daniela Lima, Laura Guimarães, C Marisa R Almeida, Catarina Teixeira, L Filipe C Castro, Miguel M Santos   +9 more
doaj   +1 more source

Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood

Disease Models & Mechanisms, 2015
Adipogenesis is accompanied by differentiation of adipose tissue-derived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs.
Laura Llobet, Janne M. Toivonen, Julio Montoya, Eduardo Ruiz-Pesini, Ester López-Gallardo   +4 more
doaj   +1 more source

Exposure to Metal Mixtures and Childhood Adiposity: An Examination of Periods of Heightened Susceptibility Between Gestation and Late Childhood

Pediatric Obesity, Volume 20, Issue 12, December 2025.
ABSTRACT Introduction Childhood obesity is a public health concern. Studies have investigated the effects of metal mixtures on childhood obesity but none have identified periods of heightened susceptibility of exposure. We identified the periods by investigating the association of metal mixture, measured at four time points, with adiposity.
Janice M. Y. Hu, Michael M. Borghese, Mandy Fisher, Joseph M. Braun, Katherine M. Morrison, Mark R. Palmert, Linda Booij, Constadina Panagiotopoulos, Jillian Ashley‐Martin   +8 more
wiley   +1 more source

Obesogenic environment – intervention opportunities

Jornal de Pediatria, 2016
To evaluate environmental obesogenic-related factors, such as physical activity in neighborhoods and schools, nutritional behavior, and intervention programs.Critical analysis of literature with personal point of view from infant obesity experts and political advisors for public intervention.Although obesity is a public health problem affecting several
Fisberg, Mauro, Maximino, Priscila, Kain Berkovic, Juliana, Kovalskys, Irina   +3 more
openaire   +8 more sources