Results 21 to 30 of about 781 (170)
Endocrine disrupters as obesogens [PDF]
Molecular and Cellular Endocrinology, 2009 The recent dramatic rise in obesity rates is an alarming global health trend that consumes an ever increasing portion of health care budgets in Western countries. The root cause of obesity is thought to be a prolonged positive energy balance. Hence, the major focus of preventative programs for obesity has been to target overeating and inadequate ...
Felix, Grün, Bruce, Blumberg
openaire +2 more sources
Minireview: The Case for Obesogens [PDF]
Molecular Endocrinology, 2009 AbstractObesity and obesity-related disorders, such as type 2 diabetes, hypertension, and cardiovascular disease, are epidemic in Western countries, particularly the United States. The conventional wisdom holds that obesity is primarily the result of a positive energy balance, i.e. too many calories in and too few calories burned.
Felix, Grün, Bruce, Blumberg
openaire +2 more sources
Current Research Approaches and Challenges in the Obesogen Field
Frontiers in Endocrinology, 2019 Obesity is a worldwide pandemic that also contributes to the increased incidence of other diseases such as type 2 diabetes. Increased obesity is generally ascribed to positive energy balance.
Raquel Chamorro-Garcia +3 more
doaj +1 more source
Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion. [PDF]
Environ ToxicolABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Feijó M +9 more
europepmc +2 more sources
Expression of obesity markers and Persistent Organic Pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis? [PDF]
PLoS ONE, 2014 Persistent Organic Pollutants (POPs) accumulate in adipose tissue and some are described to possess endocrine disrupting capacities. Therefore, it is important to evaluate their effects on key endocrine pathways in adipose tissue (AT), to further ...
Anna Pereira-Fernandes +8 more
doaj +1 more source
Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect. [PDF]
PLoS ONE, 2013 Recently the environmental obesogen hypothesis has been formulated, proposing a role for endocrine disrupting compounds (EDCs) in the development of obesity. To evaluate this hypothesis, a screening system for obesogenic compounds is urgently needed.
Anna Pereira-Fernandes +6 more
doaj +1 more source
Toxics, 2020 Mercury (Hg) has obesogenic properties. However, the associated health outcomes of population-level mercury exposure were unclear. This study investigated the relationships between blood mercury levels and obesity-related outcomes such as hyperlipidemia ...
Seungho Lee +6 more
doaj +1 more source
Toxics, 2018 For the majority of lipophilic compounds, adipose tissue is traditionally considered as a storage depot and only rarely as a target organ. Meanwhile, abnormalities in adipose tissue physiology induced by chemical exposure may contribute to the current ...
Aser Abrha, Alexander Suvorov
doaj +1 more source
History of the Obesogen Field: Looking Back to Look Forward
Frontiers in Endocrinology, 2019 The Obesogen field developed from two separate scientific research areas, endocrine disruptors and the Developmental Origins of Health and Disease (DOHaD).
Jerrold J. Heindel
doaj +1 more source
Frontiers in Endocrinology, 2019 Obesity and metabolic disorders are of great societal concern and generate substantial human health care costs globally. Interventions have resulted in only minimal impacts on disrupting this worsening health trend, increasing attention on putative ...
Christopher D. Kassotis +1 more
doaj +1 more source