The obesogenic side of Genistein [PDF]
Frontiers in Endocrinology, 2023 Genistein (GN) has been highly recommended for its medicinal properties like anticancer, antidiabetic, antihyperlipidemic, antiviral, and antioxidant activities among others. Recently, scientists realized that Genistein is an endocrine disruptor.
Jia Xiang +14 more
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Curcumin Opposes Perfluorodecanoic Acid–Induced Adipogenesis Through the PPARγ/C/EBPα Axis in 3T3-L1 Cells [PDF]
Toxics(1) Background: Perfluorodecanoic acid (PFDA), a persistent perfluoroalkyl obesogen, promotes adipogenesis, yet whether its effects can be pharmacologically opposed remains unknown.
Ayten Darcan +2 more
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Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure
Frontiers in Endocrinology, 2021 Obesity and metabolic disorders have become a worldwide pandemic affecting millions of people. Although obesity is a multifaceted disease, there is growing evidence supporting the obesogen hypothesis, which proposes that exposure to a subset of endocrine
Bruce Blumberg, Toshi Shioda
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Bisphenol A and DDT disrupt adipocyte function in the mammary gland: implications for breast cancer risk and progression [PDF]
Frontiers in OncologyAs breast cancer incidence continues to rise worldwide, there is a pressing need to understand the environmental factors that contribute to its development.
Sarah M. Bernhardt +2 more
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Obesogenic Dysregulation of Human Periprostatic Adipose Tissue Promotes the Viability of Prostate Cells and Reduces Their Sensitivity to Docetaxel and Cabazitaxel [PDF]
Medical SciencesBackground: Periprostatic adipose tissue (PPAT) has been shown to play a significant role in prostate cancer (PCa) development and progression. This relationship is further exacerbated by obesity, as PPAT-secreted factors increase PCa aggressiveness and ...
Mariana Feijó +9 more
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Metabolites, 2022 Obesogens such as tributyltin (TBT) are xenobiotic compounds that promote obesity, in part by distorting the normal balance of lipid metabolism. The obesogenic effects of TBT can be observed in directly exposed (F1 and F2 generations) and also subsequent
Bruce Blumberg +2 more
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Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBT
Environment International, 2021 Background: Endocrine disrupting chemicals (EDCs) contribute to the etiology of metabolic disorders such as obesity, insulin resistance and hepatic dysfunction. Concern is growing about the consequences of perinatal EDC exposure on disease predisposition
Raquel Chamorro-Garcia +2 more
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Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity [PDF]
Nature CommunicationsEffects of prenatal environmental exposures can be transmitted across generations through the germline without DNA mutations, an example of transgenerational epigenetic inheritance.
Richard C. Chang +14 more
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Identification of pharmaceuticals and environmental contaminants as obesogens inducing a locomotion-independent thrifty phenotype [PDF]
Communications BiologyObesity is a global pandemic that affects people of all ages. While behavioral, nutritional, and socioeconomic factors all contribute to weight gain, other factors in our immediate environment play an insidious role in the prevalence of obesity. Exposure
Sara Al Kassir +6 more
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Dietary Aluminum Exposure Is More Closely Linked to Antioxidant Dynamics than to Body Mass Index [PDF]
ToxicsThe association between aluminum exposure and obesity remains uncertain. This study investigated whether aluminum exposure (dietary, serum, and urinary) is linked to obesity and whether dietary antioxidant capacity moderates this relationship. A total of
Ozge Yesildemir +6 more
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