Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure [PDF]
Frontiers in Endocrinology, 2021 Obesity and metabolic disorders have become a worldwide pandemic affecting millions of people. Although obesity is a multifaceted disease, there is growing evidence supporting the obesogen hypothesis, which proposes that exposure to a subset of endocrine
Toshihiro Shioda, Bruce Blumberg
exaly +6 more sources
Editorial: Obesogens in the XXI century: Emerging health challenges. [PDF]
Front Endocrinol (Lausanne), 2022 The global prevalence of overweight and obesity has risen dramatically in recent decades. Obesity is a major public health problem, recognized by the World Health Organization as one of the most important public health challenges of the 21st century (1).
Sousa ACA +3 more
europepmc +6 more sources
Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen [PDF]
Metabolites, 2022 Obesogens such as tributyltin (TBT) are xenobiotic compounds that promote obesity, in part by distorting the normal balance of lipid metabolism. The obesogenic effects of TBT can be observed in directly exposed (F1 and F2 generations) and also subsequent
Bruce Blumberg, Toshihiro Shioda
exaly +4 more sources
From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach [PDF]
Nutrition Reviews, 2023 YÜcel BÜyÜkdere, Asli Akyol
exaly +4 more sources
Obesogens in Adolescence: Challenging Aspects and Prevention Strategies [PDF]
ChildrenChildhood obesity has become a global epidemic, with significant increases in prevalence over recent decades. While excessive calorie consumption and physical inactivity are known factors, emerging research highlights the role of endocrine-disrupting ...
Marina Nicolaou +4 more
doaj +4 more sources
Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals. [PDF]
, 2020 The incidence of obesity has reached an all-time high, and this increase is observed worldwide. There is a growing need to understand all the factors that contribute to obesity to effectively treat and prevent it and associated comorbidities.
Blumberg, Bruce, Egusquiza, Riann Jenay
core +3 more sources
Transgenerational Effects of the Obesogen Tributyltin on Metabolic Health in Mice: Interactions With a Western Diet [PDF]
EndocrinologyCheng-An Chang +2 more
exaly +3 more sources
Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice [PDF]
Nature Communications, 2017 Early life exposure to endocrine disrupting chemicals has been linked to increased adiposity during adulthood. Here Chamorro-García et al. show that ancestral exposure to the obesogen tributyltin causes obesity in untreated F4 generation male descendants
Raquel Chamorro-Garcia +6 more
doaj +2 more sources
Bisphenol A and DDT disrupt adipocyte function in the mammary gland: implications for breast cancer risk and progression [PDF]
Frontiers in OncologyAs breast cancer incidence continues to rise worldwide, there is a pressing need to understand the environmental factors that contribute to its development.
Sarah M. Bernhardt +2 more
doaj +2 more sources
Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop. [PDF]
Am J Clin Nutr, 2023 On September 7 and 8, 2022, Healthy Environment and Endocrine Disruptors Strategies, an Environmental Health Sciences program, convened a scientific workshop of relevant stakeholders involved in obesity, toxicology, or obesogen research to review the ...
Heindel JJ +27 more
europepmc +3 more sources