Results 31 to 40 of about 781 (170)
Transgenerational effects of obesogens
Basic & Clinical Pharmacology & Toxicology, 2019 AbstractObesity and associated disorders are now a global pandemic. The prevailing clinical model for obesity is overconsumption of calorie‐dense food and diminished physical activity (the calories in—calories out model). However, this explanation does not account for numerous recent research findings demonstrating that a variety of environmental ...
Lee, Michelle Kira, Blumberg, Bruce
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Current Research in Toxicology, 2021 Marilyn Silva.Retired from a career in toxicology and risk assessment.Increased childhood and adult obesity are associated with chlorpyrifos (CPF), an organophosphate pesticide.
Marilyn H. Silva
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Overview of the Pathophysiological Implications of Organotins on the Endocrine System
Frontiers in Endocrinology, 2018 Organotins (OTs) are pollutants that are used widely by industry as disinfectants, pesticides, and most frequently as biocides in antifouling paints.
Vinicius Bermond Marques +3 more
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Obesogenic environment and childhood obesity [PDF]
Obesity Reviews, 2020 SummaryThe increasing prevalence of obesity in youth has contributed to the growing global burden of chronic diseases (e.g. diabetes, cardiovascular diseases and cancers), which has been largely accounted for by obesogenic behaviours and environments.
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Minireview: PPARγ as the target of obesogens [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 The peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis and is medically important for its connections to obesity and the treatment of type II diabetes. Activation of this receptor by certain natural or xenobiotic compounds has been shown to stimulate adipogenesis in vitro and in vivo.
Amanda, Janesick, Bruce, Blumberg
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Globalization and modernization: an obesogenic combination [PDF]
Obesity Reviews, 2011 SummaryAnimal research has well established that a link exists between variations in corticosteroids and the proneness to excess body fat accumulation. Accordingly, it is known that adrenalectomy is an efficient approach to counteract weight gain in most animal models of obesity.
L, Huneault, M-È, Mathieu, A, Tremblay
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Secular Trend in Age at Menarche and Associated Determinants in the Valencian Population (Spain)
American Journal of Human Biology, Volume 38, Issue 9, September 2026.The graphical abstract illustrates changes in age at menarche in the Valencian population (Spain) over nearly eight decades and its association with anthropometric and sociodemographic factors. ABSTRACT Objective To assess secular trend in age at menarche spanning nearly eight decades and to explore variations in these patterns according to selected ...
Andrea Beneito +11 more
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Environmental Obesogens: Mechanisms and Controversies [PDF]
Annual Review of Pharmacology and Toxicology, 2019 Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure.
Heindel, Jerrold J, Blumberg, Bruce
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The Case for BPA as an Obesogen: Contributors to the Controversy
Frontiers in Endocrinology, 2019 Since the inception of the term endocrine disruptor, the idea that the environment is an important determinant of phenotype has motivated researchers to explore the effect of low dose exposure to BPA during organogenesis.
Beverly S. Rubin +2 more
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Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
Nature Communications, 2017 Early life exposure to endocrine disrupting chemicals has been linked to increased adiposity during adulthood. Here Chamorro-García et al. show that ancestral exposure to the obesogen tributyltin causes obesity in untreated F4 generation male descendants
Raquel Chamorro-Garcia +6 more
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