Development and Evaluation of Combined Drug Formulation for Autoject-injector, for Emergency Application in Organophosphate Poisoning [PDF]
, 2012 Atropine sulphate and pralidoxime chloride are considered as essential antidotes in the treatment of nerve agent poisoning. Now in India these antidotes are available in the form of self injectable autoinjectors.
Jain, Neeti +4 more
core +2 more sources
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning [PDF]
, 2007 The use of organophosphorus pesticides results in toxicity risk to non-target organisms. Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition.
Antonijević, Biljana +1 more
core +2 more sources
Interactions of muscarinic receptors and choline esterases: Functional examinations of esterase inhibitors in the rat. [PDF]
, 2015 Univerzita Karlova v Praze Farmaceutická fakulta v Hradci Králové Katedra biochemických věd Kandidát: Uday Kumar Killi, M.Sc. Školitel: Prof. Ing. Vladimír Wsól, Ph.D. Konzultant: Prof. Gunnar Tobin, D.D.S., Ph.D.
Killi, Kumar Uday
core
Export Control Handbook for Chemicals [PDF]
, 2019 The aim of this handbook is to correlate those chemicals under the scope of Export Control Regulations with other relevant data such as: the Combined Nomenclature code used to identify commodities in export declarations for Customs procedures, the CAS ...
ARNES NOVAU Xavier, SEVINI Filippo
core +1 more source
Improving poisoning management through (A) A pilot study to evaluate the use of the triple cholinesterase test in Organophosphorus poisoning and (B) A study on the changing profile of poisoning presenting to a tertiary care centre in South India [PDF]
, 2016 OBJECTIVES: 1. To validate the triple cholinesterase test for use in patients with organophosphorus poisoning – RBC acetylcholinesterase (AChE), Plasma butyrylcholinesterase (BChE), enzyme reactivating potential of obidoxime ex-vivo and Inhibitory ...
Sandhya, Suresh
core
Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡ [PDF]
, 2007 The organophosphorus nerve agents sarin, soman, tabun, and VX exert their toxic effects by inhibiting the action of human acetylcholinesterase, a member of the serine hydrolase superfamily of enzymes.
Cerasoli, Douglas +6 more
core +2 more sources
Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms [PDF]
, 2009 Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 – 65 – 125 – 170 – 250 – 500 nmol. The 250 nmol dose was found to be the LD50.
Adam +40 more
core +4 more sources
Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos [PDF]
, 2009 Background: Many organophosphorus (OP) insecticides have either two O-methyl or two O-ethyl groups attached to the phosphorus atom. This chemical structure affects their responsiveness to oxime-induced acetylcholinesterase (AChE) reactivation after ...
A. H. Dawson +39 more
core +2 more sources
Review of Possible Therapies in Treatment of Novichoks Poisoning and HAZMAT/CBRNE Approaches: State of the Art. [PDF]
J Clin Med, 2023 Noga M, Michalska A, Jurowski K.
europepmc +1 more source
Piridinijevi oksimi: razlozi za njihov odabir kao kauzalnih antidota protiv otrovanja organofosfatima i sadašnja rješenja za autoinjektore [PDF]
, 2006 During the last five decades, five pyridinium oximes were found to be worthy of use as antidotes against nerve agents in humans: pralidoxime, in a form of chloride or PAM-2 Cl and mesylate or P2S (against sarin, cyclosarin and VX), trimedoxime or TMB-4 ...
Milan Jokanović +1 more
core +1 more source