Protein Science, Volume 33, Issue 5, May 2024.Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan +3 more
wiley +1 more source
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats.
, 1991 The pharmacokinetics and pharmacodynamics of the oxime obidoxime (Toxogonin, 50 mg/kg iv) were investigated in anesthetized normal rats and in sarin-poisoned (50 micrograms/kg iv) rats. The kinetics were described by a two-compartment open model.
Waser PG +2 more
core +1 more source
Role of free hydrochloric acid in the low-cost regeneration of ferric chloride etchant by oxygen gas [PDF]
, 2005 This thesis concerns the development of a low cost and environment- friendly method for the regeneration of the most widely used aqueous etchant, ferric chloride, found in photochemical machining (PCM) facilities.
Jefferies, P. J.
core +4 more sources
Paraoxon and obidoxime inhibit thrombin activity in vitro.
, 2016 (A) Varying concentrations of paraoxon (500 nM, 5 μM, 28 μM, 50 μM, 0.28 mM and 0.5 mM) inhibit thrombin activity. (B) Obidoxime inhibits thrombin activity at varying concentrations.
Valery Golderman (3186672) +8 more
core +1 more source
Regulation of osmoadaptation in the moderate halophile Halobacillus halophilus : chloride, glutamate and switching osmolyte strategies [PDF]
, 2008 The moderate halophile Halobacillus halophilus is the paradigm for chloride dependent growth in prokaryotes. Recent experiments shed light on the molecular basis of the chloride dependence that is reviewed here.
Saum, Stephan H., Müller, Volker
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An investigation into the relationship between surface concrete resistivity and chloride conductivity test [PDF]
, 2014 Includes bibliographical references.The chloride conductivity test (CCT) is a South African-developed Durability Index (DI) test used for the evaluation and quantification of the quality of concrete cover.
Mutale, Lombe
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The anodic dissolution of covellite in acidic, chloride solutions [PDF]
, 2010 An electrochemical study was conducted on a stationary, synthetically produced, covellite electrode in acidic, chloride solutions at ambient conditions to investigate the dissolution behaviour of the mineral over a surface potential range from the open ...
Basson, Petrus
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, 2011 Silver – silver chloride electrodes (Ag/AgCl) for the detection of chloride ions were fabricated using thick-film technology. Five different formulations were prepared and chloride responses were investigated over time.
Wood, R.J. K +11 more
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The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro. [PDF]
PLoS One, 2016 Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential ...
Golderman V +8 more
europepmc +3 more sources
Acetylcholine and Cholinesterase in Submandibular Glands of Rats Given Armin and Obidoxime
, 1978 The effects of obidoxime, a pyridinium oxime, on the cholinesterase activity and acetylcholine content of the submandibular glands of rats poisoned with armin, an organophosphorus anticholinesterase agent, were studied.
Terzić, Milorad R. +5 more
core +1 more source