Results 11 to 20 of about 333,395 (110)

Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]

Clin Case Rep
ABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK, Nyuydzefon B, Kouomogne BAN, Siysi VV.   +3 more
europepmc   +2 more sources

Pro: Oximes should be used routinely in organophosphate poisoning

British Journal of Clinical Pharmacology, Volume 88, Issue 12, Page 5064-5069, December 2022., 2022
In poisoning with organophosphorus compounds (OP), patients can only profit from the regeneration of acetylcholinesterase, when the poison load has dropped below a toxic level. Every measure that allows an increase of synaptic acetylcholinesterase (AChE) activity at the earliest is essential for timely termination of the cholinergic crisis.
Horst Thiermann, Franz Worek
wiley   +1 more source

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Journal of Chemistry, Volume 2021, Issue 1, 2021., 2021
For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some ...
Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus, Shafaqat Ali   +8 more
wiley   +1 more source

A novel high‐performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme‐reactivating oximes obidoxime, pralidoxime, and HI‐6 in human plasma

Drug Testing and Analysis, Volume 12, Issue 7, Page 938-947, July 2020., 2020
A HPLC‐DAD method was developed and validated for single and simultaneous quantification of obidoxime, pralidoxime, and HI‐6 for pharmacokinetic studies and clinical samples. Abstract Oximes such as pralidoxime (2‐PAM), obidoxime (Obi), and HI‐6 are the only currently available therapeutic agents to reactivate inhibited acetylcholinesterase (AChE) in ...
Tamara Kranawetvogl, Dirk Steinritz, Horst Thiermann, Harald John   +3 more
wiley   +1 more source

Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Advanced Science, Volume 7, Issue 1, January 8, 2020., 2020
Butyrylcholinesterase (BChE)‐polymer‐oxime conjugates are synthesized by in situ atom transfer radical polymerization and azide‐alkyne “click” chemistry. The conjugate's activity depends on the electrostatic properties of the polymers and the oxime to BChE ratio.
Libin Zhang, Stefanie L. Baker, Hironobu Murata, Nicholas Harris, Weihang Ji, Gabriel Amitai, Krzysztof Matyjaszewski, Alan J. Russell   +7 more
wiley   +1 more source

Adsorption of obidoxime onto human serum albumin nanoparticles: Drug loading, particle size and drug release

, 2022
S.506-513The standard treatment of poisoning by organophosphorous compounds such as paraoxon includes the administration of oximes. Due to their inability to rapidly cross the blood-brain barrier (BBB) in therapeutically relevant concentrations, these ...
Worek, F., Wagner, S., Kufleitner, J., Kreuter, J., Briesen, H. von   +4 more
core   +1 more source

Smart Sensing of Nerve Agents

ChemPlusChem, Volume 89, Issue 8, August 2024.
Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi, Rossella Santonocito, Andrea Pappalardo, Giuseppe Trusso Sfrazzetto   +3 more
wiley   +1 more source

Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 27, July 18, 2024.
Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran, Kuntal Bose, Amrutha Chandran Thekkantavida, Riya Rachel Thomas, Karthika Anirudhan, Sandeep Bindra, Sooraj Sura, Haydara Ammar Hasan, Sunil Kumar, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Prashant Gahtori, Hoon Kim, Bijo Mathew   +13 more
wiley   +1 more source

The actions of chloride channel blockers, barbiturates and a benzodiazepine on Caenorhabditis elegans glutamate- and ivermectin-gated chloride channel subunits expressed in Xenopus oocytes [PDF]

, 2009
The pharmacology of Caenorhabditis elegans glutamate-gated chloride (GluCl) channels was determined by making intracellular voltage-clamp recordings from Xenopus oocytes expressing GluCl subunits. As previously reported (Cully et al.
Bush, Elizabeth, Holden-Dye, Lindy, Foreman, Richard, Walker, Robert J.   +3 more
core   +1 more source

Chloride diffusion coeficient determination for specifications [PDF]

, 2005
Presented at the 6th International Congress on Global Construction, Dundee, ScotlandThe chloride diffusion resistance of reinforced concrete can have a major influence on durability.
Richardson, Mark G., Callanan, Thomas, McNally, Ciaran, Evans, Conor   +3 more
core   +1 more source