Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model [PDF]
Regulatory Toxicology and Pharmacology, 2021 Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime, trimedoxime or HI-6 and an anticonvulsant.
Alex Cornelissen, Marloes Joosen
exaly +3 more sources
Development of a combined solution formulation of atropine sulfate and obidoxime chloride for autoinjector and evaluation of its stability. [PDF]
Iran J Pharm Res, 2013 Atropine (AT) and oximes, alone or in combination, have been proven greatly valuable therapeutics in the treatment of organophosphates intoxications. An injectable mixture of AT and obidoxime (OB) was formulated for the administration by automatic self-injector.
Ettehadi HA +3 more
europepmc +3 more sources
Quantification of atropine sulphate monohydrate and obidoxime dichloride in two-chamber autoinjectors for accessing uniformity of dosage. [PDF]
Anal Sci Adv, 2022 Abstract In the treatment of organophosphate poisoning atropine sulphate monohydrate (AT) and obidoxime dichloride (OB) play a vital role. Currently, the Austrian Armed Forces use the DOUBLEPEN OA two‐chamber autoinjector (ChemProtect) to administer these two drugs.
Spreitzer I +4 more
europepmc +2 more sources
Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]
Chemistry, 2022 Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Lindgren C +9 more
europepmc +2 more sources
Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević Biljana +3 more
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
Review of Possible Therapies in Treatment of Novichoks Poisoning and HAZMAT/CBRNE Approaches: State of the Art. [PDF]
J Clin Med, 2023 Noga M, Michalska A, Jurowski K.
europepmc +1 more source
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates. [PDF]
J Enzyme Inhib Med Chem, 2021 Lee HM +13 more
europepmc +1 more source
FDA-Approved Oximes and Their Significance in Medicinal Chemistry. [PDF]
Pharmaceuticals (Basel), 2022 Dhuguru J, Zviagin E, Skouta R.
europepmc +1 more source
Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl. [PDF]
Int J Mol Sci, 2021 Lorke DE +4 more
europepmc +1 more source