Results 121 to 130 of about 23,660,772 (290)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Space cannot substitute for time in the study of the ecosystem services-human wellbeing relationship
Geography and SustainabilityThe relationship between ecosystem services (ES) and human well-being (HWB) is fundamental to the science and practice of sustainability. However, studies have shown conflicting results, which has been attributed to the influences of indicators, contexts,
Lumeng Liu, Jianguo Wu
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Health Science ReportsBackground and Aims Although physical functions are associated with quality of life and well‐being, research on objective and subjective measures in older adults is limited.
Mohammad Bidkhori +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Deriving a Composite Indicator to Measure Well-being at Work in European Union Countries
, 2019 The objective of this paper is to display how the exposure to psychosocial risk factors impact on workers’ well-being as much as the physical risk factors, in particular showing the strength of the effect of exposure to selected risk factors existing in ...
Capecchi, S +3 more
core
, 2020 The concept of well-being is one of the oldest and most important topics in philosophy and ethics, going back to ancient Greek philosophy. Following the boom in happiness studies in the last few years it has moved to centre stage, grabbing media ...
Sarch, Alexander
core
Вестник Московского университета. Серия 14: ПсихологияBackground. The relevance of the study of the quality of professional life is due to its relationship with motivation, job efficacy, performance quality, and the psychological well-being of medical workers.
A.A. Kachina, N.N. Kharina
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source