Results 141 to 150 of about 23,660,772 (290)

Measuring objective well-being and sustainable development management

Journal of Knowledge Management, Economics and Information Technology, 2014
Achieving sustainable development is undoubtedly a goal of every society and community. What is implied here is that it is a concept that needs to be managed, i.e. a goal that one strives to achieve in a continuous and dynamic sense, including continuous and consistent measurement. This paper sheds light on analysis of objective well-being that entails
Forjan, Josipa, Freimann, Anita, Ham, Marija   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Well-being across America [PDF]

This paper uses new Behavioral Risk Factor Surveillance System data to provide the first estimates of well-being across the states of America. From this sample of 1.3 million US citizens, we analyze measures of life satisfaction and mental health ...
Oswald, Andrew J., Wu, Stephen
core  

Webs of Well-Being: the Interdependence of Personal, Relational, Organizational and Communal Well-Being

Contrary to prevalent notions that well-being is a personal issue, in this chapter we argue that it is also relational, organizational and communal. If we were to define well-being strictly in terms of subjective reports, as most of the literature on the
Prilleltensky, Ora, Prilleltensky, Isaac   +1 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Well-being and the Complexity of Poverty: A Subjective Well-being Approach [PDF]

socioeconomic indicators, subjective well-being, happiness ...
Rojas, Mariano
core  

The impact of respiratory diseases on quality of life since the pandemic: a dual perspective based on objective consumption upgrading and subjective well-being

BMC Public Health
Background The COVID-19 pandemic has exacerbated the global burden of respiratory diseases (RD), intensifying syndemic threats and the “immunity debt” effect.
Yiyan Chen, Lijun Chen
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source