Results 1 to 10 of about 371,247 (318)

Non-opioid versus Opioid Peri-operative Analgesia In Neurosurgery (NOPAIN): Study protocol for a multi-centric randomised controlled trial

Indian Journal of Anaesthesia, 2023
Background and Aims: Many patients suffer from post-operative pain after neurosurgery despite using intra-operative opioids. Opioid side effects are problematic in neurosurgical patients.
Kamath Sriganesh, Georgene Singh, Prasanna Udupi Bidkar, Manikandan Sethuraman, Srilata Moningi   +4 more
doaj   +1 more source

The Complex Maze of the Informed Consent Process: Helping to Improve Comprehension in Clinical Trial Participants with Alzheimer’s Disease

Journal of Alzheimer's Disease Reports, 2020
We intend for this article to provide a foundation toward the creation of a more patient-centric approach to the informed consent process. Our overall objectives are to promote ethical clinical research standards and procedures toward enhanced supportive
Louis X. Wong, Gail M. Bloom, Bryant Chee   +2 more
doaj   +1 more source

Experiences and perceptions of patients with psoriatic arthritis participating in a trial of faecal microbiota transplantation: a nested qualitative study

BMJ Open, 2021
Objectives Patients’ first-hand experiences of faecal microbiota transplantation (FMT) performed in a rheumatological care setting have yet to be elucidated.
Maarten de Wit, Torkell Ellingsen, Jens Kjeldsen, Camilla Schufri Klinkby, Tine Tjørnhøj-Thomsen, Jens Kristian Pedersen, Heidi Lausten Munk, Maja Skov Kragsnaes, Shaun Theodor Sødergren, Hans Christian Horn, Nanna Gram Ahlmark   +10 more
doaj   +1 more source

THE OBJECTIVITY OF POLICE TESTIMONY IN THE TRIAL EVIDENCE

Bengkoelen Justice : Jurnal Ilmu Hukum, 2023
Crime and drug abuse in Indonesia have been considered severe cases. As in the status quo, the police are now intensively arresting perpetrators of drug abuse and ensuring that the law enforcement process runs against the drug users to make them responsible for their actions before the law until the trial.
Syaiful Anwar, Lidia Br. Karo, Herlambang Herlambang   +2 more
openaire   +1 more source

The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase

Neural Plasticity, 2015
Background. Bipolar depression (BD) is a prevalent condition, with poor therapeutic options and a high degree of refractoriness. This justifies the development of novel treatment strategies, such as transcranial direct current stimulation (tDCS) that ...
Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni   +7 more
doaj   +1 more source

The trial of learning objects

ASCILITE Publications, 2006
This paper describes a project undertaken in the Australian vocational training and education (VTE) sector that sought to investigate success factors associated with the design and delivery of courses using learning objects (LOs). The project explored the strategies used by three teachers as they used digital repositories to discover learning objects ...
Ron Oliver, Mark McMahon, Peter Higgs, Rose Shum, Lisa Wait, Dominic Lou   +5 more
openaire   +1 more source

421 A Phase 1 and Randomized Phase 2 Clinical Trial of Selinexor and Temozolomide in Recurrent Glioblastoma Among Adults: The Product of a Successful Team Science Approach

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Selinexor is a novel XPO1 inhibitor that blocks nuclear export, thus impairing DNA repair and causing apoptosis. Our goal was to conduct preclinical and clinical studies to test our hypothesis that selinexor’s efficacy is boosted by ...
Frances Chow, Michael Berens, Sharon Tamir, Yosef Landesman, Christopher Walker, Mark Krailo, Steven Gore, Jana Portnow   +7 more
doaj   +1 more source

Oncology patients’ experiences in experimental medicine cancer trials: a qualitative study

BMJ Open, 2021
Objectives The study aimed to explore patients’ experiences of experimental cancer medicine (ECM) clinical trials.Design The study’s design was qualitative.
Janelle Yorke, Laurie Preston, Natalie Cook, Sally Taylor, Michelle Davies, Matthew Krebs, Fiona Thistlethwaite, Louise Carter, Chelsea Sawyer, Donna Graham   +9 more
doaj   +1 more source

A blinded, controlled trial of objective measurement in Parkinson’s disease [PDF]

npj Parkinson's Disease, 2020
AbstractMedical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson’s disease has effective therapies, but continuous objective measurement has only recently become available. This blinded, controlled study examined whether management of Parkinson’s disease was improved when clinical ...
Holly Woodrow, Malcolm K. Horne, Chathurini V. Fernando, Katya E. Kotschet, Arup Bhattacharya, Richard Blaze, Andrew Charmley, Belinda Cruse, Stephen Duma, Andrew Evans, Mina Ghaly, Blake Giarola, Amy J. Halliday, Thomas Kimber, Anand Kumar, Alexander Lehn, Kate Lilley, Andrew Ma, Neil Mahant, Salar McModie, Manju Perera, Huiliang Melissa Tang, John W. Tillett, Stephen Tisch, Antony Winkel, Christine Wools   +25 more
openaire   +3 more sources

Good clinical practice: International quality standard for clinical trials [PDF]

Stomatološki glasnik Srbije, 2003
A clinical trial is one of the most important examples of experimental studies. Clinical trials represent an indispensable tool for testing, in a rigorous scientific manner, the efficacy of new therapies.
Radulović Siniša S.
doaj   +1 more source