Results 91 to 100 of about 499,553 (301)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Speaker self-profiling through discursive indexation and syntactic encoding in Spanish radio talk
Borealis: An International Journal of Hispanic Linguistics, 2017 Syntactic and discursive choices in context can constitute resources for the interactional profiling of the direct participants. This study analyzes the frequencies with which speakers index themselves, as well as the syntactic functions they preferably ...
Miguel A. Aijón Oliva
doaj +1 more source
Advocacy and Objectivity in Science [PDF]
Three strategies for scientific research in management are examined: advocacy, induction, and multiple hypotheses. Advocacy of a single dominant hypothesis is efficient, but biased. Induction is not biased, but it is inefficient.
JS Armstrong
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Sociologies, 2020 Our contribution examines how Brazilian online media specialized in fact-checking mobilize transparency in their discursive productions during the period of the last presidential campaign (2018).
Lorreine Petters
doaj
Matura final examination in psychology: some metric properties [PDF]
Psihološka Obzorja, 2000 Matura in Slovenia consist of five subjects. The three compulsory subjects are: Mother Tongue, Mathematics and Foreign Language. Psychology is one of the two optional subjects (electives) that must be chosen from a wide range of natural sciences, foreign
Valentin Bucik
doaj
Laws, Symmetry, and Symmetry Breaking; Invariance, Conservation Principles, and Objectivity [PDF]
, 2002 Given its importance in modern physics, philosophers of science have paid surprisingly little attention to the subject of symmetries and invariances, and they have largely neglected the subtopic of symmetry breaking.
Earman, John
core
Reconstructing Bohr's Reply to EPR in Algebraic Quantum Theory
, 2011 Halvorson and Clifton have given a mathematical reconstruction of Bohr's reply to Einstein, Podolsky and Rosen (EPR), and argued that this reply is dictated by the two requirements of classicality and objectivity for the description of experimental data,
A. Einstein +18 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Léal souvenir? La photographie, la peinture et le serment de l’image fidèle
Aisthesis, 2018 The aim of this paper is to question the objectivist conception of photography by confronting it with the history – and epistemology – of the painted image.
Bertrand Rougé
doaj