Results 81 to 90 of about 104,393 (315)
Advocacy and Objectivity in Science [PDF]
Three strategies for scientific research in management are examined: advocacy, induction, and multiple hypotheses. Advocacy of a single dominant hypothesis is efficient, but biased. Induction is not biased, but it is inefficient.
JS Armstrong
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Diverse narratives of legal objectivity: an interdisciplinary perspective
, 2016 This volume presents a collection of essays on objectivity in legal discourse. Has law a distinctive type of objectivity? Is there one specific type of legal objectivity or many, depending on the observatory language utilized? Is objectivity fit for law?
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Kantowska metafizyka percepcji (Kant’s Metaphysics of Perception) [PDF]
Analiza i Egzystencja, 2009 This article treats of an issue of Kant’s the metaphysics of perception as a specific sphere where concept of sense perception within transcendental philosophy seem to be rooted into a wider context of metaphysical presuppositions. The text is an epitome
Paweł Sikora
doaj
, 2010 A number of recent books on ethics (Hirst and Patching, 2005, Tanner et al,2005, Richards, 2005, Ward, 2006) have indicated that traditional understandings of journalism "objectivity" are in need of renovation if they are to sustain the claim as a guide ...
Bowman , Leo +3 more
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, 2019 Objectivity has two aspects. It means, in the metaphysical sense, a correspondence between a statement and the way the world is independently of human conceptual activities.
FØLLESDAL, Dagfinn +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Sociologies, 2020 Our contribution examines how Brazilian online media specialized in fact-checking mobilize transparency in their discursive productions during the period of the last presidential campaign (2018).
Lorreine Petters
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source