Results 61 to 70 of about 104,393 (315)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Objectivity of Moral Judgements [PDF]
, 2006 The problem I wish to address is one that is widespread in analytic moral philosophy viz., that of transcending individuality in an attempt to develop theories and arguments that generally explain what occurs when we make moral judgements.
Brockless, Adrian
core
Bowen's recesses: from realism to inter-objectivity
, 2019 This chapter re-orients consideration of realist elements in Bowen’s short stories by framing readings according to a series of 'recesses'. The first is as a building feature designed to conceal and display, which frames a discussion of the status of ...
Johnson, Laurie
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Obsahová analýza / formální obsahová analýza / kvantitativní obsahová analýza
AntropoWebzin, 2010 Content analysis is one of the basic tools used for quantitative treatment of data. Its theoretical framework was developed mainly in connection with American sociology of communication during the second half of 20th century.
Ilona Dvořáková
doaj
Humanities Research and Projectivity: Disciplinary and Interdisciplinary Strategies of Knowledge [PDF]
Ученые записки Казанского университета: Серия Гуманитарные науки, 2016 The paper makes a distinction between the methodological strategies of humanitarian disciplinary and interdisciplinary knowledge. It is alleged that the disciplinary structure of humanities is supported by a rigid connection between the objectivity of ...
M.S. Kiseleva
doaj
, 2008 Wright's 'Truth and Objectivity' seeks to systematise a variety of anti-realist positions. I argue that many objections to the system are avoided by transposing its talk of truth into talk of warrant. However, a problem remains about debates involving '
Barton, Jon
core
Error and objectivity: cognitive illusions and qualitative research
, 2005 Psychological research has shown that cognitive illusions, of which visual illusions are just a special case, are systematic and pervasive, raising epistemological questions about how error in all forms of research can be identified and eliminated.
Paley, John, John Paley
core +1 more source