Results 101 to 110 of about 104,393 (315)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

TOWARD AN OBJECTIVE ISLAMIC STUDIES

open access: yesTeosofia: Indonesian Journal of Islamic Mysticism, 2016
One of the issues that haunts contemporary Muslim scholarship is the objectivity of the study of Islamic Studies which they strive for. Among them are groups called insiders and outsiders.
Karimatul Hasanah
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

The Distinguish and the Combination in "Research" and "Transcendence Process" In Prove Objectivity of Transcendent-Analysis and Composition of Norman L. Geisler and Allameh Tabatabai Thought [PDF]

open access: yesحکمت صدرایی
One of the important issues that has made thinkers in the field of philosophy of religion think and reflect, is the discussion of reality and, in a more scientific sense, the objectivity of the "transcendent". being real; In other words, the transcendent
Hossein Khodadadi   +3 more
doaj   +1 more source

Empirical Knowledge and Objectivity

open access: yes, 1970
There is, in the philosophical literature, a paradox which surrounds the discussion of the nature of physical reality and the possibility of our knowledge of it.
Murray, Priscilla
core  

Objectivity [PDF]

open access: yes, 2022
Objectivity may be a useful regulative ideal for inquiry, but here I ponder to what extent it may be thought of more as a political ideology than an epistemological methodology.
Toole, Briana
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Objetividade jornalística: o debate contemporâneo do conceito [PDF]

open access: yes, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-graduação em Jornalismo, Florianópolis, 2009Neste trabalho a objetividade é entendida como um dos fundamentos do jornalismo, o qual reúne ...
Demeneck, Ben-Hur
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Constructing Authenticity as an Alternative to Objectivity: A Study of Non-Fiction Journalism in Chinese Media

open access: yesJournalism and Media
In recent years, non-fiction journalism, regarded as a subset of literary and narrative journalism, has garnered significant attention in Chinese media. This trend underscores a notable departure from traditional journalistic norms of objectivity toward ...
Haiyan Wang, Yuyao Ni
doaj   +1 more source

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