Results 51 to 60 of about 58,349 (266)

Visual object affordances: Object orientation

open access: yesActa Psychologica, 2007
Five experiments systematically investigated whether orientation is a visual object property that affords action. The primary aim was to establish the existence of a pure physical affordance (PPA) of object orientation, independent of any semantic object-action associations or visually salient areas towards which visual attention might be biased. Taken
Ed, Symes, Rob, Ellis, Mike, Tucker
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Věcnost v povídkách Ladislava Dvořáka // Objectivity in short stories of Ladislav Dvořák [PDF]

open access: yesSlovo a Smysl, 2017
The article examines the prosaic works of Ladislav Dvořák (1920–1983), specifically the collection of short stories entitled Šavle meče. It analyses the construction of Dvořák’s texts with regard to their significant aspect, the connection between ...
Zuzana Pokorná
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

An object lesson in objection [PDF]

open access: yesJournal of Family Planning and Reproductive Health Care, 2008
Theres always been conscientious objection in medicine. The inherent egotistical "this is how its done and what youll do if you want to get on" attitude that medicine breeds means its often hidden. Or its tough to carry out your objection. I object to having to see patients - wait I havent finished yet - when Ive got laryngitis for instance. Most of us
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

On Solidarity: Gramsci’s Objectivity as a Corrective to Buber’s I-It

open access: yesPhenomenology and Mind, 2017
I and Thou sets out a dichotomy of human interactions between the merely objective I-It and the intense intersubjective relationship of the I-Thou, creating a problem of how one is to differentiate the I-It relations that are healthy and natural, and ...
Ryan Adams
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Climate Change Journalism: From Agony to Agonistic Debate

open access: yesDesenvolvimento e Meio Ambiente, 2017
Starting from a politicized outlook on climate change, this essay criticizes mainstream journalistic norms for failing to enable an agonistic, democratic debate about how to move forward.
Yves Pepermans, Pieter Maeseele
doaj   +1 more source

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