Results 111 to 120 of about 1,519,165 (389)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, Volume 19, Issue 7, Page 2056-2073, July 2025.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

What If Fiduciary Obligations Are Like Contractual Ones? [PDF]

, 2016
This essay, to appear in Contract, Status, and Fiduciary Law (Miller & Gold, 2016), explores three ways fiduciary obligations might be like contractual ones: in the methods lawmakers use or should use to determine the content of the obligation; in the ...
Klass, Gregory
core   +3 more sources

Parental Cultural Socialization of Mexican-American Adolescents' Family Obligation Values and Behaviors.

Child Development, 2015
The current study examined how parents' cultural socialization efforts contribute to adolescents' family obligation values and behaviors and how these processes may depend upon the relational climate at home.
K. M. Tsai, Eva H. Telzer, N. Gonzales, A. Fuligni   +3 more
semanticscholar   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, Volume 19, Issue 7, Page 2109-2119, July 2025.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Obligation to Speak Truth

, 2016
Kathy Ianello has been pilloried for disclosing Truth as she discerns it. It troubles me that much of the criticism levied against her seems disengaged from her original words, or from the ample evidence of excellence in her long career; it horrifies and
Fee, Christopher R.
core  

Obligation Blackwell Games and p-Automata [PDF]

, 2013
We recently introduced p-automata, automata that read discrete-time Markov chains. We used turn-based stochastic parity games to define acceptance of Markov chains by a subclass of p-automata.
Chatterjee, Krishnendu, Piterman, Nir
core  

AYNİ HAKLARIN TEMİNAT İŞLEVİ

Ankara Sosyal Bilimler Üniversitesi Hukuk Fakültesi Dergisi, 2019
Ayni hakların teminat amacıyla kullanılması ekonomik ihtiyaçların gelişimiyle doğru orantılıdır. Rehin hakkının ekonomik ihtiyaçları karşılamadaki sınırlılığı, mülkiyet hakkının teminat amacıyla kullanılması zorunluluğunu doğurmuştur.
Erman BENLİ
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Extraterritorial Application and Customary Norm Assessment of Non-Refoulement: The Legality of Australia\u27s \u27Turn-Back\u27 Policy [PDF]

, 2015
This article considers whether the Commonwealth Government’s border protection policy of turning back asylum seeker boats breaches its international obligation not to refoule refugees, as imposed under the Refugee Convention art 33(1). In addressing this
Mansfield, James
core   +1 more source

Do We Have Reasons to Obey the Law? [PDF]

, 2020
Instead of the question, ‘do we have an obligation to obey the law?,’ we should first ask the more modest question, ‘do we have reasons to obey the law?’ This paper offers a new account of the notion of the content-independence of legal reasons in terms ...
Flanigan, Edmund Tweedy
core