Results 121 to 130 of about 1,519,165 (389)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Unnecessary inconvenience and compensation within the party wall legislation [PDF]

, 2000
Examines the obligations to avoid unnecessary inconvenience and to pay compensation for loss or damage within the Party Wall, etc. Act 1996. Considers the argument that the two obligations are directly related.
Chynoweth, P
core   +2 more sources

Expressions of obligation, duty, and necessity in Livonian

Eesti ja Soome-ugri Keeleteaduse Ajakiri, 2014
In Livonian, obligation, duty, and necessity are expressed mainly by means of constructions containing a finite form of the auxiliary verbs piḑīm ‘must’ and piḑīks ‘should have to’, tūlda ‘to come’, lǟ’dõ ‘to go’, vȱlda ‘to be’ and līdõ ‘shall, will ...
Tiit-Rein Viitso
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Moment of Truth: The Special Relationship of the Federal Government to Alaska Natives and Their Tribes — Update and Issue Analysis [PDF]

, 1981
Beyond considering the present state of the statutory relationship between the federal government and Alaska Natives, this analysis focuses on the power of Congress and the Executive Branch to change the relationship.
Conn, Stephen, Garber, Bart Kaloa, Haycox, Stephen   +2 more
core  

Hanefî-Mâtürîdî Kelâm Okulunda Aklî Teklif

Yakın Doğu Üniversitesi İlahiyat Fakültesi Dergisi
İslam düşüncesinde teklif konusunun farklı mezhepler tarafından vahiy ve akıl ekseninde değerlendirilmesi, bağımsız insan varlığının ilahi sorumluluğunun kaynağıyla ilgili problemlere çözüm bulmaya yönelik bir faaliyettir.
Yunus Eraslan
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The Legal Obligations Arising Out of Treaty Relations between China and Other States [PDF]

, 1919
W. W. Willoughby, Min-chʿien T. Z. Tyau
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Is There a Duty to Militarily Intervene to Stop a Genocide? [PDF]

, 2016
Is there is a moral obligation to militarily intervene in another state to stop a genocide from happening (if this can be done with proportionate force)?
Steinhoff, Uwe
core   +1 more source