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Ob/ob mice as a model of delayed gastric emptying
Journal of Diabetes and its Complications, 2003Diabetic gastroparesis is a well-recognized delay of gastric emptying in diabetic patients. We assessed the gastric emptying rate in ob/ob mice, a genetic model of obesity and diabetes. The basal gastric emptying rate in 22- to 27-week-old ob/ob mice was significantly lower than that in 10- to 11-week-old ob/ob mice ...
Akihiro, Asakawa +6 more
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Interactions of Doxazosin with Insulin or Glucagon in the ob/ob Mouse
Journal of Cardiovascular Pharmacology, 1989Doxazosin, a selective inhibitor of alpha 1-adrenergic receptors, when administered alone or in combination with insulin or glucagon to mature ob/ob mice, consistently lowered levels of triglycerides, cholesterol, glycerol, and lactate and increased levels of beta-hydroxybutyrate and glucose.
A C, Swindell, J J, Valentine
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Iron Metabolism in Genetically Obese (ob/ob) Mice
The Journal of Nutrition, 1988Several reports in the clinical literature suggest that obese children may be at risk for developing iron deficiency. Here the absorption, retention, tissue distribution and tissue levels of iron were compared in lean (+/?) and obese (ob/ob) C57BL/6J mice to examine the impact of obesity on the iron status of this animal model.
M L, Failla, M L, Kennedy, M L, Chen
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Glucocerebroside Ameliorates the Metabolic Syndrome in OB/OB Mice
The Journal of Pharmacology and Experimental Therapeutics, 2006Glucocerebroside (GC) is a naturally occurring glycolipid that may alter natural killer T (NKT) cell function. To determine the effect of GC on the metabolic derangements and immune profile in leptin-deficient mice, Ob/Ob mice were treated by daily injections of GC for 8 weeks and followed for various metabolic and immunological parameters.
Maya, Margalit +8 more
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Thyroid Hormone Responses to Feeding in ob/ob Mice
Hormone and Metabolic Research, 1989Many of the disturbances which characterize adult C57BL/6 ob/ob mice, including obesity, hypometabolism and hypothermia could arise from reduced circulating levels of thyrotropin and thyroid hormones. In the present study, measurement of these hormones in ad libitum-fed obese and lean mice housed at 22 degrees C revealed that mutant mice had levels of ...
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Zinc Metabolism in Genetically Obese (ob/ob) Mice
The Journal of Nutrition, 1987Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from those in lean controls. In the present studies the absorption, retention and tissue distribution of zinc and constitutive levels of zinc-metallothionein (Zn-MT) in selected tissues were
M L, Kennedy, M L, Failla
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The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice
Metabolism, 1976The development of obesity, hyperglycemia, and hyperinsulinemia, was examined in obese-hyperglycemic (ob/ob) mice, their lean littermates, and homozygous lean mice (+/+) between 17 days and 8 wk of age. By 4 wk of age ob/ob mice displayed many of the metabolic characteristics that are typical of the syndrome in adult animals, including elevated ...
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