Results 1 to 10 of about 1,780,625 (304)

Adipose-derived mesenchymal stem cells from obese mice prevent body weight gain and hyperglycemia

Stem Cell Research & Therapy, 2021
Changes that occur to the stem cell microenvironment with disease are a major consideration that may affect the behavior and potential therapeutic efficacy of mesenchymal stem cells (MSCs).
Yicheng Qi, Wen Liu, Xiangsheng Wang, Nan Lu, Minglan Yang, Wei Liu, Jing Ma, Wei Liu, Wenjie Zhang, Shengxian Li   +9 more
doaj   +1 more source

Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level

Frontiers in Nutrition, 2021
Resolvin E1 (RvE1) is an immunoresolvent that is synthesized from eicosapentaenoic acid and can bind the receptor ERV1/ChemR23. We previously showed activation of the RvE1-ChemR23 axis improves hyperglycemia and hyperinsulinemia of obese mice; however ...
Abrar E. Al-Shaer, Anandita Pal, Saame Raza Shaikh   +2 more
doaj   +1 more source

PI3Kα inhibition reduces obesity in mice

Aging, 2016
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best known health beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditure, reduced nutrient storage, and protection from obesity.
Lopez-Guadamillas, Elena, Muñoz-Martin, Maribel, Martinez, Sonia, Pastor, Joaquin, Fernandez-Marcos, Pablo J., Serrano, Manuel   +5 more
openaire   +3 more sources

Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy

International Journal of Endocrinology, 2015
Objective. Tauroursodeoxycholic acid (TUDCA) has been considered an important regulator of energy metabolism in obesity. However, the mechanism underlying how TUDCA is involved in insulin resistance is not fully understood. We tested the effects of TUDCA
Qinyue Guo, Qindong Shi, Huixia Li, Jiali Liu, Shufang Wu, Hongzhi Sun, Bo Zhou   +6 more
doaj   +1 more source

Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma

Respiratory Research, 2020
Background Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To date, lung tissue regeneration and
Pengfei Xu, Fabian Gärtner, Adrian Gihring, Congxing Liu, Timo Burster, Martin Wabitsch, Uwe Knippschild, Stephan Paschke   +7 more
doaj   +1 more source

Obesity impairs resistance to Leishmania major infection in C57BL/6 mice.

PLoS Neglected Tropical Diseases, 2020
An association between increased susceptibility to infectious diseases and obesity has been described as a result of impaired immunity in obese individuals. It is not clear whether a similar linkage can be drawn between obesity and parasitic diseases. To
Vinicius Dantas Martins, Franciele Carolina Silva, Felipe Caixeta, Matheus Batista Carneiro, Graziele Ribeiro Goes, Lícia Torres, Sara Cândida Barbosa, Leonardo Vaz, Nivea Carolina Paiva, Cláudia Martins Carneiro, Leda Quercia Vieira, Ana Maria Caetano Faria, Tatiani Uceli Maioli   +12 more
doaj   +1 more source

Influence of Obesity on the Organization of the Extracellular Matrix and Satellite Cell Functions After Combined Muscle and Thorax Trauma in C57BL/6J Mice

Frontiers in Physiology, 2020
Obesity has been described as a major factor of health risk in modern society. Next to intricately linked comorbidities like coronary artery disease or diabetes, an influence of obesity on regeneration after muscle injury has been described previously ...
Adrian Gihring, Fabian Gärtner, Congxing Liu, Markus Hoenicka, Martin Wabitsch, Uwe Knippschild, Pengfei Xu   +6 more
doaj   +1 more source

Hepatic Runx1t1 improves body fat index after endurance exercise in obese mice

Scientific Reports, 2023
Endurance exercise could attenuate obesity induced by high fat diet (HFD). Thus, the purpose of this study was to explore the crucial targets that play key roles in the improvement of body fat index (BFI) in obese mice by endurance exercise.
Ning Jiang, Zhe Wang, Xiangying Guo, Zifu Peng, Yimin He, Qian Wang, Huaduo Wu, Yunlong Cui   +7 more
doaj   +1 more source

Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity? [PDF]

PLoS ONE, 2013
It has been hypothesized that a reduced nephron endowment exacerbates the hypertensive and renal effects of obesity. We therefore examined the impact of diet-induced obesity on renal structure and function, and arterial pressure in a genetic model of ...
Seshini Gurusinghe, Russell D Brown, Xiaochu Cai, Chrishan S Samuel, Sharon D Ricardo, Merlin C Thomas, Michelle M Kett   +6 more
doaj   +1 more source

Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice.

PLoS ONE, 2014
Synphilin-1 is a cytoplasmic protein that has been shown to be involved in the control of energy balance. Previously, we reported on the generation of a human synphilin-1 transgenic mouse model (SP1), in which overexpression of human synphilin-1 resulted
Xueping Li, Yada Treesukosol, Alexander Moghadam, Megan Smith, Erica Ofeldt, Dejun Yang, Tianxia Li, Kellie Tamashiro, Pique Choi, Timothy H Moran, Wanli W Smith   +10 more
doaj   +1 more source