Results 41 to 50 of about 240,716 (309)

Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy

International Journal of Endocrinology, 2015
Objective. Tauroursodeoxycholic acid (TUDCA) has been considered an important regulator of energy metabolism in obesity. However, the mechanism underlying how TUDCA is involved in insulin resistance is not fully understood. We tested the effects of TUDCA
Qinyue Guo, Qindong Shi, Huixia Li, Jiali Liu, Shufang Wu, Hongzhi Sun, Bo Zhou   +6 more
doaj   +1 more source

Obesity impairs resistance to Leishmania major infection in C57BL/6 mice.

PLoS Neglected Tropical Diseases, 2020
An association between increased susceptibility to infectious diseases and obesity has been described as a result of impaired immunity in obese individuals. It is not clear whether a similar linkage can be drawn between obesity and parasitic diseases. To
Vinicius Dantas Martins, Franciele Carolina Silva, Felipe Caixeta, Matheus Batista Carneiro, Graziele Ribeiro Goes, Lícia Torres, Sara Cândida Barbosa, Leonardo Vaz, Nivea Carolina Paiva, Cláudia Martins Carneiro, Leda Quercia Vieira, Ana Maria Caetano Faria, Tatiani Uceli Maioli   +12 more
doaj   +1 more source

Influence of Obesity on the Organization of the Extracellular Matrix and Satellite Cell Functions After Combined Muscle and Thorax Trauma in C57BL/6J Mice

Frontiers in Physiology, 2020
Obesity has been described as a major factor of health risk in modern society. Next to intricately linked comorbidities like coronary artery disease or diabetes, an influence of obesity on regeneration after muscle injury has been described previously ...
Adrian Gihring, Fabian Gärtner, Congxing Liu, Markus Hoenicka, Martin Wabitsch, Uwe Knippschild, Pengfei Xu   +6 more
doaj   +1 more source

Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity? [PDF]

PLoS ONE, 2013
It has been hypothesized that a reduced nephron endowment exacerbates the hypertensive and renal effects of obesity. We therefore examined the impact of diet-induced obesity on renal structure and function, and arterial pressure in a genetic model of ...
Seshini Gurusinghe, Russell D Brown, Xiaochu Cai, Chrishan S Samuel, Sharon D Ricardo, Merlin C Thomas, Michelle M Kett   +6 more
doaj   +1 more source

Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation [PDF]

, 2020
The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark
Choi, Jang Hyun, Choi, Sun Sil, Jang, Hyunduk, Khim, Keon Woo, Lee, Jae Min, Lee, Yo Han, Oh, Sei Ryang, Park, Jiyoung, Park, Mi Hyeon, Ryu, Hyung Won   +9 more
core   +1 more source

Spontaneous restoration of functional β‐cell mass in obese SM/J mice

Physiological Reports, 2020
Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are unknown.
Mario A. Miranda, Caryn Carson, Celine L. St. Pierre, Juan F. Macias‐Velasco, Jing W. Hughes, Marcus Kunzmann, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson   +8 more
doaj   +1 more source

Hepatic Runx1t1 improves body fat index after endurance exercise in obese mice

Scientific Reports, 2023
Endurance exercise could attenuate obesity induced by high fat diet (HFD). Thus, the purpose of this study was to explore the crucial targets that play key roles in the improvement of body fat index (BFI) in obese mice by endurance exercise.
Ning Jiang, Zhe Wang, Xiangying Guo, Zifu Peng, Yimin He, Qian Wang, Huaduo Wu, Yunlong Cui   +7 more
doaj   +1 more source

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua, Chou, Caroline Ei Ne, Dawson, David W, Eibl, Guido, French, Samuel, Hao, Fang, Hines, O Joe, Moro, Aune, Rozengurt, Enrique, Schmidt, Andrea I, Sinnett-Smith, James   +10 more
core   +2 more sources

Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice. [PDF]

PLoS ONE, 2015
Obesity is associated with insulin resistance and the increased development of vascular complications. Previously, we have demonstrated that thrombospondin1 (TSP1) regulates macrophage function and contributes to obesity associated inflammation and ...
Hasiyeti Maimaitiyiming, Kate Clemons, Qi Zhou, Heather Norman, Shuxia Wang   +4 more
doaj   +1 more source

Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC

Gut Microbes, 2022
Obesity causes chronic inflammation and changes in gut microbiome. However, how this contributes to poor survival and therapy resistance in patients with pancreatic cancer remain undetermined.
Kousik Kesh, Roberto Mendez, Beatriz Mateo-Victoriano, Vanessa T Garrido, Brittany Durden, Vineet K Gupta, Alfredo Oliveras Reyes, Nipun Merchant, Jashodeep Datta, Santanu Banerjee, Sulagna Banerjee   +10 more
doaj   +1 more source