Results 41 to 50 of about 1,780,625 (304)
The Physiology of Obese-Hyperglycemic Mice [ob/obMice] [PDF]
The Scientific World JOURNAL, 2007 This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemicob/obmice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance.
openaire +3 more sources
Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice. [PDF]
PLoS ONE, 2015 Obesity is associated with insulin resistance and the increased development of vascular complications. Previously, we have demonstrated that thrombospondin1 (TSP1) regulates macrophage function and contributes to obesity associated inflammation and ...
Hasiyeti Maimaitiyiming +4 more
doaj +1 more source
Gut Microbes, 2022 Obesity causes chronic inflammation and changes in gut microbiome. However, how this contributes to poor survival and therapy resistance in patients with pancreatic cancer remain undetermined.
Kousik Kesh +10 more
doaj +1 more source
Nutrition & Metabolism, 2012 Background Obesity associates with low-grade inflammation and adipose tissue remodeling. Using sensitive high-throughput protein arrays we here investigated adipose tissue cytokine and angiogenesis-related protein profiles from obese and lean mice, and ...
Kurki Eveliina +4 more
doaj +1 more source
Effect of acute ozone exposure on the lung metabolomes of obese and lean mice. [PDF]
PLoS ONE, 2017 Pulmonary responses to the air pollutant, ozone, are increased in obesity. Both obesity and ozone cause changes in systemic metabolism. Consequently, we examined the impact of ozone on the lung metabolomes of obese and lean mice.
Joel Andrew Mathews +6 more
doaj +1 more source
The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice [PDF]
, 2009 Objective: The growth and development of adipose tissue are thought to be associated with angiogenesis and extracellular matrix remodeling. Since the composition of the herbal extract called Ob-X has been shown to have both anti-angiogenic and matrix ...
Min-Young Kim +9 more
core
Baseline lung function in obese mice.
, 2015 Baseline lung function in obese mice.
Jung-Won Park (128726) +3 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
p53 Activation in Adipocytes of Obese Mice [PDF]
Journal of Biological Chemistry, 2003 The tumor suppressor p53 is a transcription factor that activates or represses its target genes after various genotoxic stresses. We have previously shown that sterol regulatory element-binding protein-1 (SREBP-1), a key transcriptional regulator of triglyceride synthesis, and the lipogenic enzymes under its control are markedly suppressed in ...
Naoya, Yahagi +17 more
openaire +2 more sources
Obese mice have smaller lymph nodes with fewer lymphatic vessels.
, 2013 A. Representative immunofluorescent staining (LYVE-1 = red; DAPI = blue) of inguinal lymph nodes (2× magnification) harvested from control (left panels) and obese (right panels) wild-type and RAG mice. B.
Babak J. Mehrara (298083) +8 more
core +1 more source