Results 51 to 60 of about 1,780,625 (304)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. [PDF]

PLoS ONE, 2014
During the recent H1N1 outbreak, obese patients had worsened lung injury and increased mortality. We used a murine model of influenza A pneumonia to test the hypothesis that leptin receptor deficiency might explain the enhanced mortality in obese ...
Kathryn A Radigan, Luisa Morales-Nebreda, Saul Soberanes, Trevor Nicholson, Recep Nigdelioglu, Takugo Cho, Monica Chi, Robert B Hamanaka, Alexander V Misharin, Harris Perlman, G R Scott Budinger, Gökhan M Mutlu   +11 more
doaj   +1 more source

Exercise treatment restores IFN-α and IFN-stimulated gene expression in obese mice.

, 2015
8A) Interferon-stimulated genes or inflammasome-related genes measured by PCR microarray in mRNA isolated from the lungs of non-obese mice at day one p.i. The fold-change shown reflects non-obese exercise mice relative to non-obese non-exercise mice.
Kyoungjin J. Yoon (760467), Christina M. Loiacono (464393), Molly M. Olson (760463), Kristi J. Warren (760462), Marian L. Kohut (464394), Mackenzie L. Cahill (760465), Todd A. Wyatt (760466), Nicholas J. Thompson (760464)   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pyruvate induces torpor in obese mice [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Mice can reduce their body temperature and metabolic rate and enter torpor when they are subjected to cold, calorie deprivation, or administration of some metabolic inhibitors. Here we show that administration of pyruvate, a key metabolic intermediate and substrate for gluconeogenesis, induces torpor in obese mice ...
Marion, Soto, Lucie, Orliaguet, Michelle L, Reyzer, M Lisa, Manier, Richard M, Caprioli, C Ronald, Kahn   +5 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Exercise-Induced Browning of White Adipose Tissue and Improving Skeletal Muscle Insulin Sensitivity in Obese/Non-obese Growing Mice: Do Not Neglect Exosomal miR-27a

Frontiers in Nutrition, 2022
Exercise is considered as a favorable measure to prevent and treat childhood obesity. However, the underlying mechanisms of exercise-induced beneficial effects and the difference between obese and non-obese individuals are largely unclear.
Dongxue Wang, Dongxue Wang, Xihuan Zhang, Xihuan Zhang, Yibai Li, Lihong Jia, Lingling Zhai, Wei Wei, Li Zhang, Li Zhang, Hongkun Jiang, Yinglong Bai   +11 more
doaj   +1 more source

Is energy expenditure reduced in obese mice with mutations in the leptin/leptin receptor genes? [PDF]

, 2020
Rodents with mutations in the leptin, or leptin receptor, genes have been extensively used to investigate the regulation of energy balance and the factors that underlie the development of obesity.
Arch, Jonathan R.S., Arch, Jonathan RS, Trayhurn, Paul   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source