Results 31 to 40 of about 1,780,625 (304)

In vivo laboratory practicals in research-led teaching: An example using glucose tolerance tests in lean and obese mice [PDF]

, 2011
The use of animal models is an essential part of medical research and drug development. The essential skills required to be able to do such research includes experimental design, statistical analysis and the actual handling and treating of the animals ...
Ian M. Kinchin, Sprake, J.A, Sprake, Juliet, King, Aileen, Juliet A. Sprake, Bowe, James, King, A; id_orcid, James E. Bowe, Bowe, J, Kinchin, I.M, Aileen J.F. King   +10 more
core   +1 more source

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice

Pharmaceutical Biology, 2017
Context: Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy in treating obesity is limited.
Xin Yang, Qian Wang, Zeng-run Pang, Meng-ran Pan, Wen Zhang   +4 more
doaj   +1 more source

Alterations in the mammary gland and tumor microenvironment of formerly obese mice

BMC Cancer, 2023
Background Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and adipose tissue fibrosis.
Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Yue Xiong, Abbey E. Williams, Lisa M. Arendt   +5 more
doaj   +1 more source

Somatostatin in the pancreas and hypothalamus of obese mice [PDF]

Diabetologia, 1979
The pancreatic content of somatostatin, insulin, and glucagon and the hypothalamic content of somatostatin were examined in ob/ob mice at various ages and in goldthioglucose-obese mice. The total pancreatic content of somatostatin was increased in ob/ob mice compared to controls: 92 ng vs 75 ng (a 22% increase) at 2 months of age; 208 ng vs 131 ng (a ...
Dolais, kitabgi J, Marchand, brustel Y, Freychet, P   +2 more
openaire   +2 more sources

Effect of histamine in SD mice compared to obese mice.

, 2022
The graph illustrates the percentage of change (%) in diameter of SD mice compared to obese mice after stimulation with histamine. n = 4 mice per group. Data represent the mean ± SEM.
Oscar Aguila-Torres (14135516), Ricardo Corro-Hernández (14135513), Amelia Rios (5100233), Jesús Santana-Solano (823151), Bruno Escalante (797673)   +4 more
core   +1 more source

Effects of vasopressin on lipogenesis in obese mice [PDF]

FEBS Letters, 1981
Vasopressin is one of several catabolic hormones which have been shown to inhibit fatty acid synthesis in lean mice [ 11. Using the perfused liver preparation, it can be shown that the inhibitory action ofvasopressin is rapid in onset suggesting that vasopressin exerts a primary inhibitory effect on lipogenesis which probably occurs at the acetyl CoA ...
Edwards, M.W., Brooks, Sarah L., Gove, C.D., Hems, D.A., Cawthorne, M.A.   +4 more
openaire   +2 more sources

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese[S]

Journal of Lipid Research, 2016
Alcohol- and obesity-related liver diseases often coexist. The hepatic lipidomics due to alcohol and obesity interaction is unknown. We characterized the hepatic lipidome due to 1) alcohol consumption in lean and obese mice and 2) obesity and alcohol ...
Puneet Puri, Jun Xu, Terhi Vihervaara, Riikka Katainen, Kim Ekroos, Kalyani Daita, Hae-Ki Min, Andrew Joyce, Faridoddin Mirshahi, Hidekazu Tsukamoto, Arun J. Sanyal   +10 more
doaj   +1 more source

Data_Sheet_1_More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged by Escherichia coli.DOCX

, 2022
Obese mice presented lower mortality to non-fatal pneumonia induced by Escherichia coli (E. coli) than the non-obese mice. However, it remained obscure whether the intestine contributed to the protective effect of obese mice with infection.
Bin Tian (5723), Zhijun Zhong (139658), Zhihua Ren (630854), Ya Wang (1202), Shuang Liang (211832), Zhicai Zuo (797522), Dongjie Cai (10101184), Liuhong Shen (442141), Yao Cen (1597588), Liping Gou (10101190), Jing Fang (170284), Xiaoping Ma (740600)   +11 more
core   +1 more source

WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism

FEBS Open Bio, 2020
White adipose tissue (WAT) is important for maintenance of homeostasis, because it stores energy and secretes adipokines. The WAT of obese people demonstrates mitochondrial dysfunction, accompanied by oxidative stress, which leads to insulin resistance ...
Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Yoshimi Nakagawa, Takeshi Nakamura, Hiroshi Kawabe, Yoshikazu Higami   +14 more
doaj   +1 more source

Spontaneous restoration of functional β‐cell mass in obese SM/J mice

Physiological Reports, 2020
Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are unknown.
Mario A. Miranda, Caryn Carson, Celine L. St. Pierre, Juan F. Macias‐Velasco, Jing W. Hughes, Marcus Kunzmann, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson   +8 more
doaj   +1 more source