Results 31 to 40 of about 240,716 (309)

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese[S]

Journal of Lipid Research, 2016
Alcohol- and obesity-related liver diseases often coexist. The hepatic lipidomics due to alcohol and obesity interaction is unknown. We characterized the hepatic lipidome due to 1) alcohol consumption in lean and obese mice and 2) obesity and alcohol ...
Puneet Puri, Jun Xu, Terhi Vihervaara, Riikka Katainen, Kim Ekroos, Kalyani Daita, Hae-Ki Min, Andrew Joyce, Faridoddin Mirshahi, Hidekazu Tsukamoto, Arun J. Sanyal   +10 more
doaj   +1 more source

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]

, 2014
The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Evans, Ronald M, Franck, Niclas, Hah, Nasun, Heinrichsdorff, Jan, Mayoral, Rafael, Morinaga, Hidetaka, Oh, Da Young, Olefsky, Jerrold M, Osborn, Olivia, Pessentheiner, Ariane R, Walenta, Evelyn   +14 more
core   +2 more sources

PI3Kα inhibition reduces obesity in mice

Aging, 2016
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best known health beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditure, reduced nutrient storage, and protection from obesity.
Lopez-Guadamillas, Elena, Muñoz-Martin, Maribel, Martinez, Sonia, Pastor, Joaquin, Fernandez-Marcos, Pablo J., Serrano, Manuel   +5 more
openaire   +3 more sources

Malaria and obesity: obese mice are resistant to cerebral malaria [PDF]

Malaria Journal, 2008
The relationship between malaria and obesity are largely unknown. This is partly due to the fact that malaria occurs mainly in tropical areas where, until recently, obesity was not prevalent. It now appears, however, that obesity is emerging as a problem in developing countries.
Robert, Vincent, Bourgouin, Catherine, Depoix, Delphine, Thouvenot, C, Lombard, M-N, Grellier, Philippe   +5 more
openaire   +4 more sources

Adipose-derived mesenchymal stem cells from obese mice prevent body weight gain and hyperglycemia

Stem Cell Research & Therapy, 2021
Changes that occur to the stem cell microenvironment with disease are a major consideration that may affect the behavior and potential therapeutic efficacy of mesenchymal stem cells (MSCs).
Yicheng Qi, Wen Liu, Xiangsheng Wang, Nan Lu, Minglan Yang, Wei Liu, Jing Ma, Wei Liu, Wenjie Zhang, Shengxian Li   +9 more
doaj   +1 more source

Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level

Frontiers in Nutrition, 2021
Resolvin E1 (RvE1) is an immunoresolvent that is synthesized from eicosapentaenoic acid and can bind the receptor ERV1/ChemR23. We previously showed activation of the RvE1-ChemR23 axis improves hyperglycemia and hyperinsulinemia of obese mice; however ...
Abrar E. Al-Shaer, Anandita Pal, Saame Raza Shaikh   +2 more
doaj   +1 more source

WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism

FEBS Open Bio, 2020
White adipose tissue (WAT) is important for maintenance of homeostasis, because it stores energy and secretes adipokines. The WAT of obese people demonstrates mitochondrial dysfunction, accompanied by oxidative stress, which leads to insulin resistance ...
Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Yoshimi Nakagawa, Takeshi Nakamura, Hiroshi Kawabe, Yoshikazu Higami   +14 more
doaj   +1 more source

High fat diet causes rebound weight gain [PDF]

, 2012
Acknowledgements This work was funded by a grant from Action Medical Research (SP4581).
McNay, David E. G., Speakman, John R.
core   +1 more source

Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma

Respiratory Research, 2020
Background Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To date, lung tissue regeneration and
Pengfei Xu, Fabian Gärtner, Adrian Gihring, Congxing Liu, Timo Burster, Martin Wabitsch, Uwe Knippschild, Stephan Paschke   +7 more
doaj   +1 more source

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]

, 2018
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G., Bamshad, David, Bellner, Lars, Favero, Gaia, Grant, Ilana, Lebovics, Edward, Meissner, Aliza, Raffaele, Marco, Rezzani, Rita, Rodella, Luigi F., Sacerdoti, David, Schragenheim, Joseph, Singh, Shailendra P., Vanella, Luca   +13 more
core   +1 more source