Results 11 to 20 of about 1,780,625 (304)

Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice [PDF]

PLoS ONE, 2022
Background Non-alcoholic fatty liver disease (NAFLD) ranks first among liver diseases in Western countries. NAFLD is typically associated with obesity and diabetes, however it also develops in lean individuals without metabolic syndrome.
Emma Hymel, Elizabeth Vlock, Kurt W. Fisher, Paraskevi A. Farazi   +3 more
doaj   +3 more sources

Exercise Improves Host Response to Influenza Viral Infection in Obese and Non-Obese Mice through Different Mechanisms. [PDF]

PLoS ONE, 2015
Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight loss is not achieved, but it has not been determined if regular exercise improves immune ...
Kristi J Warren, Molly M Olson, Nicholas J Thompson, Mackenzie L Cahill, Todd A Wyatt, Kyoungjin J Yoon, Christina M Loiacono, Marian L Kohut   +7 more
doaj   +3 more sources

Oxidative Stress-Dependent Coronary Endothelial Dysfunction in Obese Mice. [PDF]

PLoS ONE, 2015
Obesity is involved in several cardiovascular diseases including coronary artery disease and endothelial dysfunction. Endothelial Endothelium vasodilator and vasoconstrictor agonists play a key role in regulation of vascular tone.
Ana María Gamez-Mendez, Hilda Vargas-Robles, Amelia Ríos, Bruno Escalante   +3 more
doaj   +2 more sources

Allergic Airway Responses in Obese Mice [PDF]

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale Epidemiologic data indicate an increased incidence of asthma in the obese. Objectives To determine whether obese mice exhibit augmented pulmonary responses after allergen sensitization and challenge.
Richard A, Johnston, Ming, Zhu, Yadira M, Rivera-Sanchez, Frank L, Lu, Todd A, Theman, Lesley, Flynt, Stephanie A, Shore   +6 more
openaire   +3 more sources

Hormonal and enzymatic analysis for pancreas of diabetic and obese mice in Iraq [PDF]

Caspian Journal of Environmental Sciences, 2022
For our knowledge, this appears to be first Iraqi study aimed for detection the concentration of pancreatic exocrine enzymes and endocrine hormones as well as lipid profile in obese, diabetic as well as obese/diabetic mice.
Nasreen Habib Humaidan Al-Moussawi
doaj   +1 more source

Fish oil suppresses obesity more potently in lean mice than in diet-induced obese mice but ameliorates steatosis in such obese mice [PDF]

Bioscience, Biotechnology, and Biochemistry, 2021
ABSTRACT This study sought to clarify the antiobesity effects of fish oil (FO) in terms of prevention and amelioration. An isocaloric diet composed of lard or FO was given to lean C57BL/6J mice for the study of prevention and high-fat diet-induced obese (DIO) mice for the study of amelioration for 4 weeks.
Sachiko, Okue, Eimi, Ishikawa, Ren, Nakahara, Tsubasa, Ito, Takumi, Okura, Mana, Sakae, Atsushi, Miura, Yori, Ozaki-Masuzawa, Takashi, Hosono, Taiichiro, Seki   +9 more
openaire   +2 more sources

Obesity Alters cytokine signaling and gut microbiome in septic mice

Innate Immunity, 2023
Sepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old
Lauren Bodilly, Lauren Williamson, Patrick Lahni, Matthew N. Alder, David B. Haslam, Jennifer M. Kaplan   +5 more
doaj   +1 more source

Activation of AMPK ameliorates acute severe pancreatitis by suppressing pancreatic acinar cell necroptosis in obese mice models

Cell Death Discovery, 2023
Obese people with acute pancreatitis (AP) have an increased risk of developing severe acute pancreatitis (SAP), which prolongs the length of hospital stay and increases mortality.
Kunlei Wang, Anbang Zhao, Dilinigeer Tayier, Kai Tan, Wenjing Song, Qian Cheng, Xinyin Li, Zhinan Chen, Qifeng Wei, Yufeng Yuan, Zhiyong Yang   +10 more
doaj   +1 more source

Dapagliflozin partially restores reproductive function in MC4R KO obese female mice [PDF]

, 2022
Obese women often have certain degree of reproductive dysfunction with infertility. Although the clinical impact of obesity on female infertility has been extensively studied, the effective and targeted treatment is still lacking. Melanocortin-4-receptor
Wang, W, Cowley, M., Wu, M, Roelfsema, F., Cowley, M, Huang, Z, Cui, L., Tan, C.L., Huang, L.L., Geng, F, Wu, M.J., Chen, X, Geng, F., Tan, C, Chen, X.L., Wang, W.H., Cui, L, Roelfsema, F, Huang, L, Chen, C, Huang, Z.X., Chen, C., Mengjun Wu, Lili Huang, Ferdinand Roelfsema, Fang Geng, Michael Cowley, Chunlu Tan, Chen Chen, Weihao Wang, Zhengxiang Huang, Ling Cui, Xiaolin Chen   +32 more
core   +1 more source

Cilia, tubby mice, and obesity [PDF]

Cilia, 2013
Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of ciliary signaling in the pathogenesis of this monogenic ...
Mukhopadhyay, Saikat, Jackson, Peter K
openaire   +2 more sources