Results 11 to 20 of about 240,716 (309)

Cilia, tubby mice, and obesity [PDF]

Cilia, 2013
Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of ciliary signaling in the pathogenesis of this monogenic ...
Mukhopadhyay, Saikat, Jackson, Peter K
openaire   +2 more sources

Fish oil suppresses obesity more potently in lean mice than in diet-induced obese mice but ameliorates steatosis in such obese mice [PDF]

Bioscience, Biotechnology, and Biochemistry, 2021
ABSTRACT This study sought to clarify the antiobesity effects of fish oil (FO) in terms of prevention and amelioration. An isocaloric diet composed of lard or FO was given to lean C57BL/6J mice for the study of prevention and high-fat diet-induced obese (DIO) mice for the study of amelioration for 4 weeks.
Sachiko, Okue, Eimi, Ishikawa, Ren, Nakahara, Tsubasa, Ito, Takumi, Okura, Mana, Sakae, Atsushi, Miura, Yori, Ozaki-Masuzawa, Takashi, Hosono, Taiichiro, Seki   +9 more
openaire   +2 more sources

Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. [PDF]

PLoS ONE, 2013
A positive relationship between obesity and asthma has been well documented. The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses.
Marina Ciarallo Calixto, Letícia Lintomen, Diana Majoli André, Luiz Osório Leiria, Danilo Ferreira, Camilo Lellis-Santos, Gabriel Forato Anhê, Silvana Bordin, Richardt Gama Landgraf, Edson Antunes   +9 more
doaj   +1 more source

Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice. [PDF]

PLoS ONE, 2014
Synphilin-1 is a cytoplasmic protein that has been shown to be involved in the control of energy balance. Previously, we reported on the generation of a human synphilin-1 transgenic mouse model (SP1), in which overexpression of human synphilin-1 resulted
Xueping Li, Yada Treesukosol, Alexander Moghadam, Megan Smith, Erica Ofeldt, Dejun Yang, Tianxia Li, Kellie Tamashiro, Pique Choi, Timothy H Moran, Wanli W Smith   +10 more
doaj   +1 more source

Metabolic effects of CCL5 deficiency in lean and obese mice

Frontiers in Immunology, 2023
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of immunocytes in adipose tissue during obesity. Chemokine (C-C motif) ligand 5
Hui Zhou, Hui Zhou, Xiyan Liao, Xiyan Liao, Qin Zeng, Qin Zeng, Haowei Zhang, Haowei Zhang, Jianfeng Song, Jianfeng Song, Wanyu Hu, Wanyu Hu, Xiaoxiao Sun, Xiaoxiao Sun, Yujin Ding, Yujin Ding, Dandan Wang, Dandan Wang, Yalun Xiao, Yalun Xiao, Tuo Deng, Tuo Deng, Tuo Deng   +22 more
doaj   +1 more source

Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice [PDF]

, 2020
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on ...
Claro Cala, Carmen María, Herrera González, María Dolores, Miñano Sánchez, Francisco Javier, Pérez Montero , Marta, Quintela, José Carlos, Rodríguez Rodríguez , Rosalía, Álvarez de Sotomayor Paz, María   +6 more
core   +1 more source

Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Muscle weakness is a frequently occurring complication of sepsis, associated with increased morbidity and mortality. Interestingly, obesity attenuates sepsis‐induced muscle wasting and weakness.
Wouter Vankrunkelsven, Sarah Derde, Jan Gunst, Sarah Vander Perre, Emiel Declerck, Lies Pauwels, Inge Derese, Greet Van den Berghe, Lies Langouche   +8 more
doaj   +1 more source

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources

Alterations in oral [1-(14)C] 18:1n-9 distribution in lean wild-type and genetically obese (ob/ob) mice. [PDF]

PLoS ONE, 2015
Obesity may result from altered fatty acid (FA) disposal. Altered FA distribution in obese individuals is poorly understood. Lean wild-type C57BL/6J and obese C57BL/6Job/ob mice received an oral dose of [1-(14)C]18:1n-9 (oleic acid), and the ...
Xinxia Wang, Jie Feng, Caihua Yu, Qingwu W Shen, Yizhen Wang   +4 more
doaj   +1 more source

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]

, 2019
There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A, Dang, Hoa, Kaufman, Daniel L, Sun, Ren, Tian, Jide, Wu, Ting-Ting, Yong, Jing   +6 more
core   +2 more sources