Results 81 to 90 of about 82,731 (339)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Treatment of Heavy Postmenopausal Bleeding With Comorbidities in Septuagenarian, Octogenarian and Nonagenarian (Case Series)

Pakistan Armed Forces Medical Journal
Few postmenopausal patients with a history of postmenopausal bleeding with comorbidities and unfit for general anaesthesia.These could not be treated with conservative treatments and developed moderate to severe anaemia.
Mamuna Qayum, Abdul Bari, Nomira Waheed, Saba Zaman, Javeria Naeem, Osama Ali   +5 more
doaj   +1 more source

The Physiology of Obese-Hyperglycemic Mice [ob/obMice] [PDF]

The Scientific World JOURNAL, 2007
This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemicob/obmice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance.
openaire   +3 more sources

An improved E-OBS pan-European gridded data set for global radiation

, 2023
Jouke de Baar, Gerard van der Schrier, Wouter Knap, Else van den Besselaar   +3 more
openalex   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Association between oxidative balance scores and peripheral artery disease in US adults: a cross-sectional study

Frontiers in Nutrition
BackgroundThe Oxidative Balance Score (OBS) quantifies the overall oxidative stress burden, with higher scores indicating greater antioxidant (relative to prooxidant) activity.
Min Zhou, Min Zhou, Peng-Fei He, Peng-Fei He, Keren Zhang, Li-Juan Deng, Ning Wang, Gang Wang, Guang-Yao Yang, Shang Ju   +9 more
doaj   +1 more source

Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

PLOS ONE, 2016
Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that sirtuins (SIRTs) modulate this transition.
Xianfeng Wang, Nancy L Buechler, Ayana Martin, Jonathan Wells, Barbara Yoza, Charles E McCall, Vidula Vachharajani   +6 more
openaire   +4 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Four Years Maternal Missed Mortality Ratio and Mortality Index at A Tertiary  Care Hospital in Azad Kashmir

Pakistan Armed Forces Medical Journal
Objective: To calculate the Maternal Near Miss Mortality Ratio and Mortality Index at a tertiary care hospital in a developing country with limited healthcare resources. Study Design: Retrospective analytical study.
Ambreen Ehsan, Maryam Zubair, Abida Islam, Amera Tariq, Umairah Yaqub, Nosheena Shabbir   +5 more
doaj   +1 more source

Data for ambient noise analysis around Tristan da Cunha in the South Atlantic from OBS data

, 2022
Hao Zhang
openalex   +1 more source