Results 131 to 140 of about 740,500 (344)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Methodology for Observation of House Types
Annals of The Tohoku Geographycal Asocciation, 1972 In order to undertstand aspects of houses in today's settlement it is important to be able to observe house types speedily and extensively. One method is to utilize the automobile. Using a pre-determined classification scheme, two observers may rapidly relay the data to a third person for recording.
openaire +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Scientific methodology. Analytical observational studies
Angiología, 2023 Antonio Martín Conejero +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Monitoring solar-type stars for luminosity variations [PDF]
Since 1984, researchers have made more than 1500 differential photometric b (471 nm) and y (551 nm) measurements of three dozen solar-like lower main sequence stars whose chromospheric activity was previosly studied by O. C. Wilson.
Lockwood, G. W., Skiff, B. A.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
E-balonmano.com: Revista de Ciencias del Deporte, 2015 El objetivo del presente estudio es describir la incidencia que tiene el tiro libre sobre el resultado final del encuentro, además de ver que otros factores pueden influir en el porcentaje final de aciertos de tiros libres, comparando para ello las ligas
José Vicente García Tormo +3 more
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