Results 111 to 120 of about 343,769 (301)

Blending Observational Methods: Possibilities, Strategies, and Challenges

, 2008
Qualitative researchers have used the observational strategies of video recording and participant observation to investigate specific phenomena. Although there have been recent advances in the separate use of these strategies, there is evidence that ...
Bottorff, Joan L., Hewat, Roberta, Paterson, Barbara L.   +2 more
core  

A primer on observational measurement

, 2018
Observational measurement plays an integral role in a variety of scientific endeavors within biology, psychology, sociology, education, medicine, and marketing.
Jeffrey M. Girard, Jeffrey F Cohn
core   +2 more sources

Observing Neurodiversity, Observing Methodology: Ethnography in Pandemic Times

International Journal of Qualitative Methods
Ethnographic researchers have long relied upon observation as a powerful means to learn about social relations. This paper discusses research observation that was conducted as a part of an institutional ethnography (IE) investigating how people use the language and ideas of neurodiversity across different settings. While our research protocol initially
Margaret F. Gibson, bridget livingstone, Hannah Monroe, Sarah Leo, Julia Gruson-Wood, Paula Crockford   +5 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Desarrollo de la Autonomía del Alumnado de Primaria en Educación Física a través de un proceso de investigación-acción. [Development of Autonomy of Elementary Students in Physical Education through a process of action research].

Revista Internacional de Ciencias del Deporte, 2015
Partiendo del enfoque competencial del sistema educativo, y considerando que una de las competencias en la etapa de educación primaria está relacionada con la autonomía e iniciativa personal, los objetivos que se plantean en este estudio son (a) desvelar
Francisco Jiménez-Jiménez, Carmen Rosa Sánchez-López   +1 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A Methodology for Effective Metadata Design in Earth Observation

, 2017
The satellite images have become an essential source of information to address and analyze environmental issues quickly, repeatedly and in a reliable way. The increasing number of remotely sensed images are the first impediments for data discovery, access and processing.
Desconnets, Jean-Christophe, Mougenot, I., Chahdi, H.   +2 more
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Observational Scaffolding for Learning Analytics: A Methodological Proposal

, 2018
Temporal analysis of learning data is attracting the interest of researchers, and a growing body of Learning Analytics (LA) research applies lag sequential analysis. However, lack of methodological frameworks that guide the data gathering and analysis poses multiple conceptual, methodological, analytical and technical challenges. While observation as a
Jairo Rodríguez-Medina, María Jesús Rodríguez-Triana, Maka Eradze, Sara García-Sastre   +3 more
openaire   +2 more sources