Results 101 to 110 of about 343,769 (301)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IDENTIFICACIÓN DE VARIABLES SIGNIFICATIVAS EN EL SAQUE DE ESQUINA EN FÚTBOL FEMENINO: COMPARACIÓN CON EL FÚTBOL MASCULINO [Identification of significant variables in the corner kick in women's football: comparison with men's football]

E-balonmano.com: Revista de Ciencias del Deporte, 2019
En los últimos años se constata un aumento de los trabajos de naturaleza científica centrada en el fútbol femenino. En cambio, los estudios de naturaleza táctica, y más concretamente las situaciones estáticas del juego, todavía permanecen al margen del ...
Rubén Maneiro, Claudio Alberto Casal Sanjurjo, Antonio Ardá Suárez, Jose Luís Losada López   +3 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Incidencia del nivel de competición en el rendimiento del bloqueo en voleibol femenino. [Impact on competition level performance block female volleyball].

Revista Internacional de Ciencias del Deporte, 2014
En este trabajo se ha registrado, analizado y valorado la acción de juego del bloqueo en voleibol femenino, para hacer una descripción de dicho gesto técnico-táctico en función al nivel de competición.
Jorge Montoro-Escaño, Antonio Hernández-Mendo   +1 more
doaj   +1 more source

New Methodological Perspectives on Observation and Experimentation in Science [PDF]

, 2010
[Abstract] Observation and experimentation are central topics of philosophy and methodology of science. The empirical sciences have commonly been associated to observational and experimental processes, because they have been considered crucial for testing the contents of these.
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effect of match location on the playing style of teams coached by ‘Pep’ Guardiola

Frontiers in Psychology
IntroductionAnalysis in football seeks to find the performance factors that bring teams closer to success.MethodsThis study aims to analyze the playing styles of two teams managed by Pep Guardiola (F.C.
Luis Pueyo, Víctor Murillo, Javier Álvarez, Alberto Sarmiento, Mario Amatria   +4 more
doaj   +1 more source

Detection and Selection of Behavioral Patterns Using Theme: A Concrete Example in Grassroots Soccer

Sports, 2017
Observational methodology provides a rigorous yet flexible framework for capturing behaviors over time to allow for the performance of subsequent diachronic analyses of the data captured.
Mario Amatria, Daniel Lapresa, Javier Arana, M. Teresa Anguera, Gudberg K. Jonsson   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Methodology for Observation of House Types

Annals of The Tohoku Geographycal Asocciation, 1972
In order to undertstand aspects of houses in today's settlement it is important to be able to observe house types speedily and extensively. One method is to utilize the automobile. Using a pre-determined classification scheme, two observers may rapidly relay the data to a third person for recording.
openaire   +2 more sources