Results 91 to 100 of about 343,769 (301)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Propensity score matching with missing covariates via iterated, sequential multiple imputation

, 2011
In many observational studies, analysts estimate causal effects using propensity score matching. Estimation of propensity scores is complicated when covariate values intended for collection are in fact missing. To handle the missing data, one approach is
Reiter, Jerome P., Mitra, Robin
core  

Observational Causality Testing

, 2023
In prior work we have introduced an asymptotic threshold of sufficient randomness for causal inference from observational data. In this paper we extend that prior work in three main ways.
Tshiaba, Placede, Knaeble, Brian, Osting, Braxton   +2 more
core  

Design, Validation, and Reliability of an Observation Instrument for Technical and Tactical Actions of the Offense Phase in Soccer

Frontiers in Psychology, 2019
The use of observational methodology in the sports context provides coaches and other sports professionals with flexible tools that adapt to their needs. In collective sports, the use of these instruments is common for the technical and tactical analysis
Enrique Ortega-Toro, Antonio García-Angulo, José María Giménez-Egido, Francisco Javier García-Angulo, José Manuel Palao   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Introduction to monograph on observational data analysis [PDF]

, 2018
In our introduction, we express our gratitude to Anales de Psicología for publishing this monograph, which embodies many of the achievements that have been made in observational data analysis over the past quarter of a century.
Anguera Argilaga, María Teresa
core   +1 more source

Mediation analysis methods used in observational research: a scoping review and recommendations

, 2021
Background Mediation analysis methodology underwent many advancements throughout the years, with the most recent and important advancement being the development of causal mediation analysis based on the counterfactual framework.
Valente, Matthew J., Jos W. R. Twisk, Martijn W. Heymans, Heymans, Martijn W., Lamp, Sophia J., Judith J. M. Rijnhart, David P. MacKinnon, Rijnhart, Judith J. M., MacKinnon, David P., Twisk, Jos W. R., Matthew J. Valente, Sophia J. Lamp   +11 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Bias in observational studies on the effectiveness of in hospital use of hydroxychloroquine in COVID-19 [PDF]

, 2023
Purpose: During the first waves of the coronavirus pandemic, evidence on potential effective treatments was urgently needed. Results from observational studies on the effectiveness of hydroxychloroquine (HCQ) were conflicting, potentially due to biases ...
Klungel, Olaf H., Hempenius, M., Gardarsdottir, H., Groenwold, Rolf H.H., de Boer, Anthonius, Bots, Sophie H.   +5 more
core  

TEMPORAL QUALITY OF RECORDS IN HANDBALL

E-balonmano.com: Revista de Ciencias del Deporte, 2019
This work is an exploratory study to increase data quality control, by using temporal correlation coefficients. The consolidation of the observational methodology (Anguera, 2017) has been preceded by improvements of a different nature. It was based on an
Miguel Pic Aguilar
doaj