Results 131 to 140 of about 4,109,796 (295)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Guidelines for reporting evaluations based on observational methodology
Background: Observational methodology is one of the most suitable research designs for evaluating fidelity of implementation, especially in complex interventions.
Chacón-Moscoso, Salvador +3 more
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A new application of contextualist methodology in case research
, 2006 Contextualist methodology is the main focus of discussion in this paper, and its attributes as a rigorous approach to case study methodology are discussed. In a departure from the usual practice of applying this methodology to processes of organisational
Chapman, Judith A.
core
E-balonmano.com: Revista de Ciencias del Deporte, 2015 El objetivo del presente estudio es describir la incidencia que tiene el tiro libre sobre el resultado final del encuentro, además de ver que otros factores pueden influir en el porcentaje final de aciertos de tiros libres, comparando para ello las ligas
José Vicente García Tormo +3 more
doaj
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
, 1982 Logic, Methodology and Philosophy of Science VI.Includes bibliographical references and index.Electronic reproduction.Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version
Cohen, L. Jonathan(Laurence Jonathan) +1 more
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The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review [PDF]
ObjectivesObservational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol.
Leducq, Sophie +10 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source