Results 61 to 70 of about 740,500 (344)

A new framework for extracting coarse-grained models from time series with multiscale structure

, 2015
In many applications it is desirable to infer coarse-grained models from observational data. The observed process often corresponds only to a few selected degrees of freedom of a high-dimensional dynamical system with multiple time scales.
Kalliadasis, Serafim, Krumscheid, Sebastian, Pavliotis, Grigorios A.   +2 more
core   +1 more source

Overcoming the Circular Problem for \gamma-ray Bursts in Cosmological Global Fitting Analysis [PDF]

, 2008
Due to the lack of low redshift long Gamma-Ray Bursts (GRBs), the circular problem has been a severe obstacle for using GRBs as cosmological candles.
Amati L., Firmani C., Gong‐Bo Zhao, Hong Li, Jie Liu, Jun‐Qing Xia, Masetti N., Xinmin Zhang, Zu‐Hui Fan   +8 more
core   +1 more source

Observing Neurodiversity, Observing Methodology: Ethnography in Pandemic Times

International Journal of Qualitative Methods
Ethnographic researchers have long relied upon observation as a powerful means to learn about social relations. This paper discusses research observation that was conducted as a part of an institutional ethnography (IE) investigating how people use the language and ideas of neurodiversity across different settings.
Margaret F. Gibson, bridget livingstone, Hannah Monroe, Sarah Leo, Julia Gruson-Wood, Paula Crockford   +5 more
openaire   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Diachronic analysis application for the detection of soccer performance standards: a case study

International Journal of Computer Science in Sport, 2020
The purpose of this study is to analyse the interactions established by Gerard Piqué, one of the world’s top defenders, within the general context of the team.
Maneiro R, Amatria M, Anguera MT
doaj   +1 more source

Guidelines for reporting evaluations based on observational methodology [PDF]

, 2015
Background: Observational methodology is one of the most suitable research designs for evaluating fi delity of implementation, especially in complex interventions.
Anguera Argilaga, María Teresa, Chacón Moscoso, Salvador, Portell Vidal, Mariona, Sanduvete Chaves, Susana   +3 more
core  

Probing the time dependence of dark energy

, 2011
A new method to investigate a possible time-dependence of the dark energy equation of state $w$ is proposed. We apply this methodology to two of the most recent data sets of type Ia supernova (Union2 and SDSS) and the baryon acoustic oscillation peak at $
A. Conley ., A. Crotts ., A.G. Riess ., C. Clarkson, D. Larson ., D. Stern, Edésio M Barboza, H. Spinrad ., J. Guy ., J. Kratochvil, J. Sollerman ., J.S Alcaniz, M. Sullivan ., N. Benitez ., P.J. McCarthy ., R.G. Abraham ., WMAP collaboration, WMAP collaboration   +17 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source