Results 111 to 120 of about 65,758,577 (259)
Expanding the evidence base in transplantation: toward a balanced approach.
, 2008 The use of a one-dimensional "hierarchy of study designs" to grade the evidence on the effectiveness of healthcare interventions is problematic as it may underestimate the limitations of randomized controlled trials and overstate those of observational ...
van der Meulen, Jan, van der Meulen, J
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
topicmodels: An R Package for Fitting Topic Models [PDF]
Topic models allow the probabilistic modeling of term frequency occurrences in documents. The fitted model can be used to estimate the similarity between documents as well as between a set of specified keywords using an additional layer of latent ...
Bettina Grün, Kurt Hornik
core
Apropos the topic : On topic-introducing expressions in Swedish
, 2019 The inquiry into topicality calls for a deeper understanding of explicit "topic markers" such as apropos and concerning, which are found in many if not all the languages of Europe.
Egerland, Verner +2 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Invariant and Metric Free Proximities for Data Matching: An R Package [PDF]
Data matching is a typical statistical problem in non experimental and/or observational studies or, more generally, in cross-sectional studies in which one or more data sets are to be compared.
Stefano Iacus, Giuseppe Porro
core
Social interest in publications on bruxism: an altmetric analysis
Brazilian Oral ResearchMetrics derived from online social platforms indicate current interest in a specific topic. This study aimed to analyze the characteristics and social interest in scientific publications on bruxism using an altmetric analysis.
Aurélio de Oliveira ROCHA +6 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Perioperative glycemic control in patients undergoing cardiac surgery
Polish Journal of Thoracic and Cardiovascular SurgeryDiabetes mellitus (DM) is one of the most common chronic diseases, affecting globally about 537 million adults. Cardiovascular disease remains the leading cause of death and medical emergencies in the DM patient population.
Dariusz Bednarski, Łukasz Krzych
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source