Results 91 to 100 of about 450,753 (263)

Sensorial changes in individuals with HTLV-1: systematic review

Revista Pesquisa em Fisioterapia, 2018
Background: Sensory function is recognized as a precursor of the movement recovery. Therefore, the symptoms presented by people with HTLV-1 can result in impairment in the performance of functional activities.
Erika Pedreira da Fonseca, Livia Aguiar Pereira, Ludmila Souza Caldas Lordelo, Rebeca Freitas Reis Nunes, Elen Batriz Carneiro Pinto   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Continuum surveys with LOFAR and synergy with future large surveys in the 1-2 GHz band

, 2009
Radio astronomy is entering the era of large surveys. This paper describes the plans for wide surveys with the LOw Frequency ARray (LOFAR) and their synergy with large surveys at higher frequencies (in particular in the 1-2 GHz band) that will be ...
Barthel, P., Best, P., Bruggen, M., Brunetti, G., Chyzy, K., Conway, J., Jarvis, M., Lehnert, M., Miley, G., Morganti, R., Rottgering, H., Snellen, I.   +11 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Supermassive Black Hole Binaries: The Search Continues

, 2014
Gravitationally bound supermassive black hole binaries (SBHBs) are thought to be a natural product of galactic mergers and growth of the large scale structure in the universe.
A. Escala, A. Escala, A. Gould, A. Gualandris, A. King, A. Loeb, A. Pancoast, A. Pancoast, A. Petiteau, A. Robinson, A. Sesana, A. Sesana, A. Sesana, A. Sesana, A. Sesana, A. Zoghbi, A.C. Fabian, A.I. MacFadyen, A.J. Barth, B. Devecchi, B. Giacomazzo, B. Kocsis, B. Kocsis, B. McKernan, B.D. Farris, B.D. Farris, B.D. Farris, C. Palenzuela, C. Palenzuela, C. Palenzuela, C. Rodriguez, C. Rodriguez, C. Roedig, C. Roedig, C.J. Nixon, C.J. Nixon, C.O. Lousto, C.O. Lousto, C.S. Reynolds, C.W. Tsai, D. Alic, D. Chapon, D. Fiacconi, D. Gerosa, D. Merritt, D.A. Kornreich, D.J. D’Orazio, D.N.C. Lin, E. Berti, E. Bon, E. Kara, E. Kara, E. Kara, E. Lusso, E. Vasiliev, E.C. Ostriker, E.M. Cackett, E.W. Bonning, F. Civano, F. Paolis De, F. Schweizer, F.K. Liu, F.M. Khan, F.M. Khan, F.M. Khan, F.M. Khan, F.M. Rieger, G. Lodato, G.A. Shields, G.A. Shields, G.A. Shields, H.L. Maness, J. Condon, J. Cuadra, J. Guedes, J.C. McKinney, J.D. Schnittman, J.D. Schnittman, J.D. Schnittman, J.E. Barnes, J.E. Barnes, J.H. Fan, J.M. Shi, J.R. Meter van, J.S. Key, K. Gebhardt, K. Hayasaki, K. Hayasaki, K. Holley-Bockelmann, K.A. Sorathia, L. Blecha, L. Blecha, L. Ferrarese, L. Mayer, L. Mayer, L.R. Corrales, L.Č. Popović, M. Campanelli, M. Dietrich, M. Dotti, M. Dotti, M. Dotti, M. Dotti, M. Dotti, M. Dotti, M. Dotti, M. Eracleous, M. Milosavljević, M. Ponce, M. Preto, M. Volonteri, M. Volonteri, M. Volonteri, M. Volonteri, M. Volonteri, M.C. Begelman, M.C. Bentz, M.C. Bentz, M.C. Bentz, M.C. Bentz, M.C. Miller, M.J. Valtonen, N. Stone, P. Amaro-Seoane, P. Artymowicz, P. Berczik, P. Jovanović, P. Moesta, P. Mösta, P. Tsalmantza, P. Uttley, P.C. Fragile, P.C. Fragile, P.J. Armitage, R. Decarli, R. Decarli, R. Gold, R. Morganti, R.M. Shannon, R.S. Barrows, R.V.E. Lovelace, S. Babak, S. Burke-Spolaor, S. Burke-Spolaor, S. Burke-Spolaor, S. Callegari, S. Callegari, S. Chandrasekhar, S. Komossa, S. Komossa, S. Komossa, S. Tang, S. Tremaine, S.C. Noble, S.D.M. White, S.M. O’Neill, T. Bode, T. Bode, T. Bogdanović, T. Bogdanović, T. Bogdanović, T. Bogdanović, T. Matteo Di, T.A. Boroson, T.L. Tanaka, V. Ravi, W. Ju, X. Liu, Y. Shen, Z. Arzoumanian   +169 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Association between food insecurity and chronic noncommunicable diseases in Brazil: a systematic review [PDF]

Revista Brasileira de Epidemiologia
Objective: To analyze the association of food insecurity (FI) with chronic noncommunicable diseases (NCDs) in the Brazilian context. Methods: The review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO).
Jackson Silva Lima Laurentino, Renatha Celiana da Silva Brito, Rônisson Thomas de Oliveira-Silva, Amanda Soares, Thaís da Conceição Pereira, Elisiandre Martins de Lima, Ana Beatriz Macêdo Venâncio dos Santos, Poliana de Araújo Palmeira   +7 more
doaj   +1 more source