Results 91 to 100 of about 65,758,577 (259)
Sensitivity analysis of the unconfoundedness assumption in observational studies [PDF]
In observational studies, the estimation of a treatment effect on an outcome of interest is often done by controlling on a set of pre-treatment characteristics (covariates). This yields an unbiased estimator of the treatment effect when the assumption of
de Luna, Xavier, Lundin, Mathias
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Cross Validation Of Neural Network Applications For Automatic New Topic Identification [PDF]
, 2005 There are recent studies in the literature on automatic topic-shift identification in Web search engine user sessions; however most of this work applied their topic-shift identification algorithms on data logs from a single search engine.
Özmutlu, H. Cenk +3 more
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Association between food insecurity and chronic noncommunicable diseases in Brazil: a systematic review [PDF]
Revista Brasileira de EpidemiologiaObjective: To analyze the association of food insecurity (FI) with chronic noncommunicable diseases (NCDs) in the Brazilian context. Methods: The review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO).
Jackson Silva Lima Laurentino +7 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Design of observational studies
, 2020 This second edition of Design of Observational Studies is both an introduction to statistical inference in observational studies and a detailed discussion of the principles that guide the design of observational studies.
Rosenbaum, Paul R
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Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Observational studies in health professional education research
, 2021 Observational studies are not uncommon in health professional education and are frequently associated with ethnography as a methodology. This article aims to provide an overview of how observational studies are used in health professional education ...
Christy Noble (13441383) +2 more
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