Results 81 to 90 of about 450,753 (263)

Inter-rater reliability of treatment fidelity and therapeutic alliance measures for psychological therapies for anxiety in young people with autism spectrum disorders [PDF]

, 2014
Objectives: This article presents work undertaken to establish inter-rater reliability for a measure of treatment fidelity and a measure of therapeutic alliance for therapies for anxiety for young people with autism spectrum disorders. The discussion and
Brown, Rachel, Chowdhury, Uttom, Iqbal, Zeinab, Murphy, Suzanne, Press, Dee A., Reynolds, Laura, Scrivener, Louise, Shaker-Naeeni, Hadi   +7 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Glucagon-like Peptide-1 Receptor Agonists: A New Frontier in Treating Alcohol Use Disorder

Brain Sciences
Background/Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which were originally developed for managing type 2 diabetes by enhancing insulin secretion and reducing appetite, have emerged as promising candidates in alcohol use disorder ...
Tyler S. Oesterle, Ming-Fen Ho
doaj   +1 more source

Anthropometric indicators of obesity in policemen: A systematic review of observational studies

International Journal of Occupational Medicine and Environmental Health, 2014
The aim of this paper was to summarize scientific literature on obesity in policemen through a systematic review of observational studies. For this purpose the following electronic databases were selected: Medline by Pubmed, CINAHL, and Scopus; and a ...
Franciele Cascaes Da Silva, Salma Stéphany Soleman Hernandez, Elizandra Gonçalves, Beatriz Angélica Valdivia Arancibia, Thiago Luis Da Silva Castro, Rudney Da Silva   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Implementing open science and reproducible research practices in mental health research through registered reports

JCPP Advances
To increase the number of pre‐registered observational studies, Journal of Child Psychology and Psychiatry (JCPP) Advances is delighted to now invite Registered Reports.
Jessie R. Baldwin, Henrik Larsson
doaj   +1 more source

PhenDisco: phenotype discovery system for the database of genotypes and phenotypes. [PDF]

, 2013
The database of genotypes and phenotypes (dbGaP) developed by the National Center for Biotechnology Information (NCBI) is a resource that contains information on various genome-wide association studies (GWAS) and is currently available via NCBI's dbGaP ...
Alipanah, Neda, Conway, Mike, Doan, Son, Farzaneh, Seena, Feupe, Stephanie Feudjio, Garland, Asher, Hsieh, Alex, Jiang, Xiaoqian, Kim, Hyeon-Eui, Lin, Ko-Wei, Ohno-Machado, Lucila, Ross, Mindy K, Walker, Rebecca, Xu, Hua, Zhang, Jing   +14 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Orexin receptor antagonists in the treatment of insomnia associated with psychiatric disorders: a systematic review

Translational Psychiatry
Insomnia is highly comorbid in patients with psychiatric disorders, including depression, bipolar disorder, and substance use disorders, and should be treated as an independent condition. Dual orexin receptor antagonists (DORAs) have been investigated as
Taro Kishi, Michinori Koebis, Michiko Sugawara, Yuka Kawatsu, Takehiro Taninaga, Nakao Iwata   +5 more
doaj   +1 more source