Results 61 to 70 of about 65,758,577 (259)

Body Mass Index, Diet-Related Factors, and Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis

Bladder Cancer, 2018
Background: Urologists are frequently confronted with questions of urinary bladder cancer (UBC) patients about what they can do to improve their prognosis. Unfortunately, it is largely unknown which lifestyle factors can influence prognosis.
Ellen Westhoff, J. Alfred Witjes, Neil E. Fleshner, Seth P. Lerner, Shahrokh F. Shariat, Gunnar Steineck, Ellen Kampman, Lambertus A. Kiemeney, Alina Vrieling   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

From observational to dynamic genetics [PDF]

, 2014
Twin and family studies have shown that most traits are at least moderately heritable. But what are the implications of finding genetic influence for the design of intervention and prevention programs?
Oliver S. P. Davis, Davis, Oliver S. P., Claire M. A. Haworth, Oliver S.P. Davis, Haworth, Claire M. A., Claire M. A. Haworth, Davis, Oliver S P, Haworth, Claire M A   +7 more
core   +1 more source

Characteristics of confirmed SARS-COV-2 reinfection cases as reported in observational studies analysed.

, 2021
Characteristics of confirmed SARS-COV-2 reinfection cases as reported in observational studies analysed.
Alba Méndez-Brito (11820158), Charbel El Bcheraoui (8673687), Sophie Alice Müller (11337826), Johanna Hanefeld (476541), Seth Kofi Abrokwa (11820155)   +4 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Motivations for investigating health inequities in observational epidemiology : a content analysis of 320 studies [PDF]

Altres ajuts: Canadian Institutes of Health Research (173269)OBJECTIVES: To enhance equity in clinical and epidemiological research, it is crucial to understand researcher motivations for conducting equity-relevant studies. Therefore, we evaluated author
Mbuagbaw, Lawrence, Funnell, Sarah, Dewidar, Omar, Wolfenden, Luke, Owusu-Addo, Ebenezer, Tugwell, Peter, Al Zubaidi, Ali, Prats, Clara Juandro, Welch, Vivian, Obuku, Ekwaro, Cuervo, L.G, Shea, Bev, Sharp, Melissa K, Jull, Janet, McHale, Georgia, Melendez-Torres, G J, Roberts, Janet Hatchet, Aliyeva, Khadija, Jahel, Fatima, Tufte, Janice, Hardy, Billie-Jo, Bhutta, Zulfiqar, Bondok, Mostafa, Alghamyan, Amjad, Abdelrazeq, Leenah, Rizvi, Anita, Horsley, Tanya, Nicholls, Stuart G, Barker, Lucy C, Greer-Smith, Regina, Huang, Jimmy, Jearvis, Alyssa, Ghogomu, Elizabeth, Elmestekawy, Nour   +33 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Guidance for umbrella reviews of observational studies: A scoping review

JCPP Advances
Background Umbrella reviews, or overviews of reviews, synthesize information using systematic reviews (SRs) as their unit of analysis. Although a formal guideline exists for reporting umbrella reviews of healthcare interventions (i.e. Preferred Reporting
Carl Zhou, Nicholas Fabiano, Arnav Gupta, Stanley Wong, Kelly D. Cobey, David Moher, Sanam Ebrahimzadeh, Jeremy Y. Ng, Elena Dragioti, Jae Il Shin, Joaquim Radua, Samuele Cortese, Beverley Shea, Nicola Veronese, Lisa Hartling, Michelle Pollock, Stefania Papatheodorou, John P. A. Ioannidis, Marco Solmi   +18 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source