Results 71 to 80 of about 450,753 (263)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Methods and perceptions of success for patient recruitment in decentralized clinical studies

Journal of Clinical and Translational Science, 2023
Patient recruitment, diversity, and retention continue to impede successful and representative clinical studies. This systematic review aims to assess the impact of decentralized methods on recruitment, retention, and diversity in recent clinical studies.
Brian L. Miyata, Barbara Tafuto, Nadina Jose   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Constraints on the Dark Side of the Universe and Observational Hubble Parameter Data [PDF]

, 2010
This paper is a review on the observational Hubble parameter data that have gained increasing attention in recent years for their illuminating power on the dark side of the universe --- the dark matter, dark energy, and the dark age. Currently, there are
Lan, Tian, Ma, Cong, Zhang, Tong-Jie
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Guidance for umbrella reviews of observational studies: A scoping review

JCPP Advances
Background Umbrella reviews, or overviews of reviews, synthesize information using systematic reviews (SRs) as their unit of analysis. Although a formal guideline exists for reporting umbrella reviews of healthcare interventions (i.e. Preferred Reporting
Carl Zhou, Nicholas Fabiano, Arnav Gupta, Stanley Wong, Kelly D. Cobey, David Moher, Sanam Ebrahimzadeh, Jeremy Y. Ng, Elena Dragioti, Jae Il Shin, Joaquim Radua, Samuele Cortese, Beverley Shea, Nicola Veronese, Lisa Hartling, Michelle Pollock, Stefania Papatheodorou, John P. A. Ioannidis, Marco Solmi   +18 more
doaj   +1 more source

Future prospects in observational galaxy evolution: towards increased resolution

, 2012
Future prospects in observational galaxy evolution are reviewed from a personal perspective. New insights will especially come from high-redshift integral field kinematic data and similar low-redshift observations in very large and definitive surveys. We
Glazebrook, Karl
core   +1 more source

Effectiveness of sensory modulation in treating sensory modulation disorders in adults with schizophrenia: a Systematic Literature Review [PDF]

, 2017
Sensory modulation, as a treatment for sensory modulation disorders in adults with psychiatric conditions, has been implemented by occupational therapists for more than two decades.
Lloyd, Chris, Machingura, Tawanda, Molineux, Matthew, Shum, David   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source