Results 71 to 80 of about 65,758,577 (259)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Observational studies of treatment effectiveness: worthwhile or worthless? [PDF]

, 2018
Observational studies which evaluate effectiveness are often viewed with skepticism owing to the fact that patients are not randomized to treatment, meaning that results are more prone to bias.
Nazareth I, Sharma, M, Petersen I, Petersen, I, Nazareth, I, Sharma M   +5 more
core  

Characteristics of included studies–observational studies.

, 2018
Characteristics of included studies–observational studies.
Amir Zarrinpar (727123), Larry J. Prokop (5233949), Eduardo L. Grunvald (5233955), Antonio Facciorusso (3594857), Siddharth Singh (3173349), Abha G. Singh (5233952), Niels Vande Casteele (5233943), William J. Sandborn (5233946), Jeffrey R. Curtis (400737)   +8 more
core   +1 more source

SHORT: A simple checklist for observational research in clinical studies

, 2021
Even though observational studies do not deliver as strong and supporting evidence as randomized controlled trials, they contribute valuable evidence for clinical decision making.
Leonhard Held, Frank Ruschitzka, Simon Schwab, Gerhard Rogler   +3 more
core   +1 more source

Glucagon-like Peptide-1 Receptor Agonists: A New Frontier in Treating Alcohol Use Disorder

Brain Sciences
Background/Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which were originally developed for managing type 2 diabetes by enhancing insulin secretion and reducing appetite, have emerged as promising candidates in alcohol use disorder ...
Tyler S. Oesterle, Ming-Fen Ho
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Implementing open science and reproducible research practices in mental health research through registered reports

JCPP Advances
To increase the number of pre‐registered observational studies, Journal of Child Psychology and Psychiatry (JCPP) Advances is delighted to now invite Registered Reports.
Jessie R. Baldwin, Henrik Larsson
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Meta-analysis of observational studies

, 2012
Observational studies such as those used to investigate lifecourse epidemiology present particular challenges for meta-analysis. This chapter discusses the differences between meta-analysis of randomised controlled trials and observational studies ...
Greenwood, DC, Darren C. Greenwood
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source