Results 51 to 60 of about 65,758,577 (259)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study characteristics of cohort studies (observational studies & retrospective studies).

, 2022
Study characteristics of cohort studies (observational studies & retrospective studies).
Malavalli Siddalingegowda Srikanth (13170357), Subramanian Ramaswamy (1856344), Madhan Ramesh (13170354), Teggina Math Pramod Kumar (13170360), Niharika Pathakamuri (13170351), Sujit Kumar Sah (13170345), Atiqulla Shariff (13170348), Krishna Undela (129851)   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The microbiota–gut–brain axis as a modulator of symptom expression in autism spectrum disorder, with exploratory insights into ADHD: evidence from a structured narrative review on paediatric population

Frontiers in Child and Adolescent Psychiatry
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are increasingly conceptualized as multisystem neurodevelopmental conditions involving behavioral, gastrointestinal, immune, and metabolic alterations.
Alessandra Carta, Maria Pia Riccio, Alessandro Miola, Alessandro Miola, Vanna Cavassa, Mariangela Valentina Puci, Giuseppe Abbracciavento, Sara Carucci, Sara Carucci, Fabio Sambataro, Fabio Sambataro, Carmela Bravaccio, Stefano Sotgiu   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Functional similarities between bimanual coordination and topic/comment structure [PDF]

, 2007
Human manual action exhibits a differential use of a non-dominant (typically, left) and a dominant (typically, right) hand. Human communication exhibits a pervasive structuring of utterances into topic and comment.
Manfred Krifka, Krifka, Manfred
core   +1 more source

Estimation of treatment effects in observational studies by recovering the assignment probabilities and the population model

, 2007
In observational studies the assignment of units to treatments is with unknown probabilities. Consequently, estimation and comparison of treatment effects based on the empirical distributions of the response under the various treatments can be biased ...
Landsman, Victoria, Pfeffermann, Danny
core   +1 more source

Exploration of Bone Alterations in Gaucher Disease Type 1: A Global and Systematic Analysis of Scientific Knowledge [PDF]

Journal of Inborn Errors of Metabolism and Screening
Gaucher disease type 1 (GD1) is the most common lysosomal storage disorder, characterized by hepatomegaly, splenomegaly, anemia, thrombocytopenia, and skeletal manifestations, which significantly affect quality of life.
Daniela Arturo-Terranova, Lina Johanna Moreno Giraldo, José María Satizabal Soto   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Time-dependent biases in observational studies of comparative effectiveness research in rheumatology. A methodological review

, 2019
Objective: To assess to what extent time-dependent biases (ie, immortal time bias (ITB) and time-lag bias (TLB)) occur in the latest rheumatology observational studies, describe their main mechanisms and increase the awareness on this ...
Iudici, Michele, Ravaud, Philippe, Riveros, Carolina, Porcher, Raphaël   +3 more
core   +1 more source